Risk of Parkinson's disease after anaesthesia and surgery

Siddharth Jain¹, Paul R Rosenbaum², Joseph G Reiter³, Alexander S Hill³, David A Wolk⁴, Sean Hashemi³, Lee A Fleisher⁵, Roderic Eckenhoff⁶, Jeffrey H Silber⁷

Affiliations

¹ Center for Outcomes Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA; The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: jains@chop.edu.
² The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA; Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA.
³ Center for Outcomes Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁴ Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
⁵ The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA; Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Center for Perioperative Outcomes Research and Transformation, University of Pennsylvania, Philadelphia, PA, USA.
⁶ Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
⁷ Center for Outcomes Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA; The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA; Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Health Care Management, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA.

PMID: 35101245
PMCID: PMC9074782
DOI: 10.1016/j.bja.2021.12.046

Risk of Parkinson's disease after anaesthesia and surgery

Siddharth Jain et al. Br J Anaesth. 2022 Apr.

. 2022 Apr;128(4):e268-e270.

doi: 10.1016/j.bja.2021.12.046. Epub 2022 Jan 29.

Authors

Siddharth Jain¹, Paul R Rosenbaum², Joseph G Reiter³, Alexander S Hill³, David A Wolk⁴, Sean Hashemi³, Lee A Fleisher⁵, Roderic Eckenhoff⁶, Jeffrey H Silber⁷

Affiliations

¹ Center for Outcomes Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA; The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: jains@chop.edu.
² The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA; Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA.
³ Center for Outcomes Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁴ Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
⁵ The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA; Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Center for Perioperative Outcomes Research and Transformation, University of Pennsylvania, Philadelphia, PA, USA.
⁶ Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
⁷ Center for Outcomes Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA; The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA; Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Health Care Management, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA.

PMID: 35101245
PMCID: PMC9074782
DOI: 10.1016/j.bja.2021.12.046

No abstract available

Keywords: Parkinson's disease; anaesthesia; appendicectomy; multivariate matching; surgery.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

1. Silber J.H., Rosenbaum P.R., Reiter J.G., et al. Alzheimer’s dementia after exposure to anesthesia and surgery in the elderly: a matched natural experiment using appendicitis. Ann Surg. 2020 doi: 10.1097/SLA.0000000000004632U. Advance Access published on November 17. - DOI - PMC - PubMed
1. Jain S., Rosenbaum P.R., Reiter J.G., et al. Using Medicare claims in identifying Alzheimer's disease and related dementias. Alzheimers Dement. 2021;17:515–524. - PMC - PubMed
1. Tan S.H., Karri V., Tay N.W.R., et al. Emerging pathways to neurodegeneration: dissecting the critical molecular mechanisms in Alzheimer's disease, Parkinson's disease. Biomed Pharmacother. 2019;111:765–777. - PubMed
1. Xie A., Gao J., Xu L., et al. Shared mechanisms of neurodegeneration in Alzheimer's disease and Parkinson's disease. Biomed Res Int. 2014;2014:648740. - PMC - PubMed
1. Ganguly G., Chakrabarti S., Chatterjee U., et al. Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease. Drug Des Devel Ther. 2017;11:797–810. - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions

Grants and funding

RF1 AG055390/AG/NIA NIH HHS/United States

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Risk of Parkinson's disease after anaesthesia and surgery

Affiliations

Risk of Parkinson's disease after anaesthesia and surgery

Authors

Affiliations

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical