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Review
. 2022 May;161(5):1360-1369.
doi: 10.1016/j.chest.2022.01.033. Epub 2022 Jan 31.

Off-Label Use and Inappropriate Dosing of Direct Oral Anticoagulants in Cardiopulmonary Disease

Ayman A Hussein  1 , Paulino Alvarez  2 , Grant Reed  3 , Gustavo A Heresi  4
Affiliations
Review

Off-Label Use and Inappropriate Dosing of Direct Oral Anticoagulants in Cardiopulmonary Disease

Ayman A Hussein et al. Chest. 2022 May.

Abstract

Direct oral anticoagulants (DOACs) are increasingly used in clinical practice and have become essential in the management of atrial fibrillation and VTE. The enthusiasm for DOACs has fueled the off-label application of these agents in cardiopulmonary disease, and their use has often outpaced the evidence supporting their application. This article reviews the evidence and current off-label use of DOACs in various cardiopulmonary disease states.

Keywords: direct oral anticoagulant; off-label use; thromboembolism.

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