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. 2022 Jan 31;12(1):1680.
doi: 10.1038/s41598-022-05769-9.

Biomarkers associated with rhythm status after cardioversion in patients with atrial fibrillation

Pascal B Meyre  1   2 , Stefanie Aeschbacher  3   4 , Steffen Blum  3   4 , Gian Voellmin  3   4 , Peter M Kastner  5 , Elisa Hennings  3   4 , Beat A Kaufmann  3   4 , Michael Kühne  3   4 , Stefan Osswald  3   4 , David Conen  6
Affiliations

Biomarkers associated with rhythm status after cardioversion in patients with atrial fibrillation

Pascal B Meyre et al. Sci Rep. .

Abstract

Biomarkers may help to improve our knowledge about the complex pathophysiology of atrial fibrillation (AF). In this study we sought to identify significant changes in biomarkers and clinical measures in patients with and without AF recurrence after electrical cardioversion. We measured 21 conventional and new biomarkers before and 30 days after electrical cardioversion and assessed the associations of changes in biomarker levels with rhythm status at follow-up. Significant between-group changes were observed for bone morphogenetic protein 10 (BMP10), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and total bilirubin. Their respective changes were - 10.4%, - 62.0% and - 25.6% in patients with sinus rhythm, and 3.1%, 1.1% and - 9.4% in patients with recurrent AF, for a between-group difference of - 13.5% (95% confidence interval [CI] - 19.3% to - 7.6%; P < 0.001), - 63.1% (95% CI - 76.6% to - 49.6%; P < 0.001) and - 16.3% (95% CI - 27.9% to - 4.7%; P = 0.007). In multivariable models, the reductions of BMP10 and NT-proBNP were significantly associated with follow-up rhythm status (β coefficient per 1 - SD decrease, - 3.85; 95% CI - 6.34 to - 1.35; P = 0.003 for BMP10 and - 5.84; 95% CI - 10.22 to - 1.47; P = 0.009 for NT-proBNP. In conclusion, changes in BMP10 und NT-proBNP levels were independently associated with rhythm status after cardioversion, suggesting that these markers may be dependent on the actual heart rhythm.

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Conflict of interest statement

Dr. Kühne reports personal fees from Bayer, personal fees from Böhringer Ingelheim, personal fees from Pfizer BMS, personal fees from Daiichi Sankyo, personal fees from Medtronic, personal fees from Biotronik, personal fees from Boston Scientific, personal fees from Johnson&Johnson, grants from Bayer, Grants from Pfizer, Grants from Boston Scientific, Grants from BMS, Grants from Biotronik. Grants from the Swiss National Science Foundation (Grant Numbers 33CS30_148474, 33CS30_177520, 32473B_176178), the Swiss Heart Foundation, the Foundation for Cardiovascular Research Basel and the University of Basel. Dr. Conen has received consultant/speaker fees from Roche Diagnostics; and BMS/Pfizer, both outside of the current work, Canada outside of the current work. The remaining authors have nothing to disclose.

Figures

Figure 1
Figure 1
Box plots of most significant percent changes in biomarker levels by rhythm status after cardioversion. Y-axis represents mean percent change in biomarker level; horizontal bars are median values; boxes, 25th and 75th percentiles; error bars, interquartile ranges; and dots, outliers.
Figure 2
Figure 2
Waterfall plots of percent changes in biomarker levels by rhythm status after cardioversion. X-axis represents individual patients, y-axis percentage change; bars are percent change of biomarker at follow-up for each patient.
See this image and copyright information in PMC

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