Published Erratum
doi: 10.1038/s41588-022-01020-3.
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Wouter van Rheenen #
1
, Rick A A van der Spek #
2
, Mark K Bakker #
2
, Joke J F A van Vugt
2
, Paul J Hop
2
, Ramona A J Zwamborn
2
, Niek de Klein
3
, Harm-Jan Westra
3
, Olivier B Bakker
3
, Patrick Deelen
3
4
, Gemma Shireby
5
, Eilis Hannon
5
, Matthieu Moisse
6
7
8
, Denis Baird
9
10
, Restuadi Restuadi
11
, Egor Dolzhenko
12
, Annelot M Dekker
2
, Klara Gawor
2
, Henk-Jan Westeneng
2
, Gijs H P Tazelaar
2
, Kristel R van Eijk
2
, Maarten Kooyman
2
, Ross P Byrne
13
, Mark Doherty
13
, Mark Heverin
14
, Ahmad Al Khleifat
15
, Alfredo Iacoangeli
15
16
17
, Aleksey Shatunov
15
, Nicola Ticozzi
18
19
, Johnathan Cooper-Knock
20
, Bradley N Smith
15
, Marta Gromicho
21
, Siddharthan Chandran
22
23
, Suvankar Pal
22
23
, Karen E Morrison
24
, Pamela J Shaw
20
, John Hardy
25
, Richard W Orrell
26
, Michael Sendtner
27
, Thomas Meyer
28
, Nazli Başak
29
, Anneke J van der Kooi
30
, Antonia Ratti
18
31
, Isabella Fogh
15
, Cinzia Gellera
32
, Giuseppe Lauria
33
34
, Stefania Corti
19
35
, Cristina Cereda
36
, Daisy Sproviero
36
, Sandra D'Alfonso
37
, Gianni Sorarù
38
, Gabriele Siciliano
39
, Massimiliano Filosto
40
, Alessandro Padovani
40
, Adriano Chiò
41
42
, Andrea Calvo
41
42
, Cristina Moglia
41
42
, Maura Brunetti
41
, Antonio Canosa
41
42
, Maurizio Grassano
41
, Ettore Beghi
43
, Elisabetta Pupillo
43
, Giancarlo Logroscino
44
, Beatrice Nefussy
45
, Alma Osmanovic
46
47
, Angelica Nordin
48
, Yossef Lerner
49
50
, Michal Zabari
49
50
, Marc Gotkine
49
50
, Robert H Baloh
51
52
, Shaughn Bell
51
52
, Patrick Vourc'h
53
54
, Philippe Corcia
54
55
, Philippe Couratier
56
57
, Stéphanie Millecamps
58
, Vincent Meininger
59
, François Salachas
58
60
, Jesus S Mora Pardina
61
, Abdelilah Assialioui
62
, Ricardo Rojas-García
63
, Patrick A Dion
64
65
, Jay P Ross
64
66
, Albert C Ludolph
67
, Jochen H Weishaupt
68
, David Brenner
68
, Axel Freischmidt
67
69
, Gilbert Bensimon
70
71
72
73
, Alexis Brice
74
, Alexandra Durr
74
, Christine A M Payan
70
, Safa Saker-Delye
75
, Nicholas W Wood
76
, Simon Topp
15
, Rosa Rademakers
77
, Lukas Tittmann
78
, Wolfgang Lieb
78
, Andre Franke
79
, Stephan Ripke
80
81
82
, Alice Braun
82
, Julia Kraft
82
, David C Whiteman
83
, Catherine M Olsen
83
, Andre G Uitterlinden
84
85
, Albert Hofman
85
, Marcella Rietschel
86
87
, Sven Cichon
88
89
90
91
, Markus M Nöthen
88
89
, Philippe Amouyel
92
; SLALOM Consortium; PARALS Consortium; SLAGEN Consortium; SLAP Consortium; Bryan J Traynor
93
94
, Andrew B Singleton
95
, Miguel Mitne Neto
96
, Ruben J Cauchi
97
, Roel A Ophoff
98
99
100
, Martina Wiedau-Pazos
101
, Catherine Lomen-Hoerth
102
, Vivianna M van Deerlin
103
, Julian Grosskreutz
104
105
, Annekathrin Roediger
104
, Nayana Gaur
104
, Alexander Jörk
104
, Tabea Barthel
104
, Erik Theele
104
, Benjamin Ilse
104
, Beatrice Stubendorff
104
, Otto W Witte
104
, Robert Steinbach
104
, Christian A Hübner
106
, Caroline Graff
107
, Lev Brylev
108
109
110
, Vera Fominykh
108
110
, Vera Demeshonok
111
, Anastasia Ataulina
108
, Boris Rogelj
112
113
114
, Blaž Koritnik
115
, Janez Zidar
115
, Metka Ravnik-Glavač
116
, Damjan Glavač
117
, Zorica Stević
118
, Vivian Drory
45
119
, Monica Povedano
62
, Ian P Blair
120
, Matthew C Kiernan
121
, Beben Benyamin
11
122
, Robert D Henderson
123
124
, Sarah Furlong
120
, Susan Mathers
125
, Pamela A McCombe
124
126
, Merrilee Needham
127
128
129
, Shyuan T Ngo
123
124
126
, Garth A Nicholson
120
130
131
, Roger Pamphlett
132
, Dominic B Rowe
120
, Frederik J Steyn
124
133
, Kelly L Williams
120
, Karen A Mather
134
135
, Perminder S Sachdev
134
136
, Anjali K Henders
11
, Leanne Wallace
11
, Mamede de Carvalho
21
, Susana Pinto
21
, Susanne Petri
46
, Markus Weber
137
, Guy A Rouleau
64
65
66
, Vincenzo Silani
18
19
, Charles J Curtis
138
139
, Gerome Breen
138
139
, Jonathan D Glass
140
, Robert H Brown Jr
141
, John E Landers
141
, Christopher E Shaw
15
, Peter M Andersen
48
, Ewout J N Groen
2
, Michael A van Es
2
, R Jeroen Pasterkamp
142
, Dongsheng Fan
143
, Fleur C Garton
11
, Allan F McRae
11
, George Davey Smith
10
144
, Tom R Gaunt
10
144
, Michael A Eberle
12
, Jonathan Mill
5
, Russell L McLaughlin
13
, Orla Hardiman
14
, Kevin P Kenna
2
142
, Naomi R Wray
11
126
, Ellen Tsai
9
, Heiko Runz
9
, Lude Franke
3
, Ammar Al-Chalabi
15
145
, Philip Van Damme
6
7
8
, Leonard H van den Berg
2
, Jan H Veldink
146
Collaborators,
Affiliations
Collaborators
-
Giancarlo Comi, Nilo Riva, Christian Lunetta, Francesca Gerardi, Maria Sofia Cotelli, Fabrizio Rinaldi, Luca Chiveri, Maria Cristina Guaita, Patrizia Perrone, Mauro Ceroni, Luca Diamanti, Carlo Ferrarese, Lucio Tremolizzo, Maria Luisa Delodovici, Giorgio Bono, Antonio Canosa, Umberto Manera, Rosario Vasta, Alessandro Bombaci, Federico Casale, Giuseppe Fuda, Paolina Salamone, Barbara Iazzolino, Laura Peotta, Paolo Cugnasco, Giovanni De Marco, Maria Claudia Torrieri, Francesca Palumbo, Salvatore Gallone, Marco Barberis, Luca Sbaiz, Salvatore Gentile, Alessandro Mauro, Letizia Mazzini, Fabiola De Marchi, Lucia Corrado, Sandra D'Alfonso, Antonio Bertolotto, Maurizio Gionco, Daniela Leotta, Enrico Odddenino, Daniele Imperiale, Roberto Cavallo, Pietro Pignatta, Marco De Mattei, Claudio Geda, Diego Maria Papurello, Graziano Gusmaroli, Cristoforo Comi, Carmelo Labate, Luigi Ruiz, Delfina Ferrandi, Eugenia Rota, Marco Aguggia, Nicoletta Di Vito, Piero Meineri, Paolo Ghiglione, Nicola Launaro, Michele Dotta, Alessia Di Sapio, Guido Giardini, Cinzia Tiloca, Silvia Peverelli, Franco Taroni, Viviana Pensato, Barbara Castellotti, Giacomo P Comi, Roberto Del Bo, Mauro Ceroni, Stella Gagliardi, Lucia Corrado, Letizia Mazzini, Flavia Raggi, Costanza Simoncini, Annalisa Lo Gerfo, Maurizio Inghilleri, Alessandra Ferlini, Isabella L Simone, Bruno Passarella, Vito Guerra, Stefano Zoccolella, Cecilia Nozzoli, Ciro Mundi, Maurizio Leone, Michele Zarrelli, Filippo Tamma, Francesco Valluzzi, Gianluigi Calabrese, Giovanni Boero, Augusto Rini
Affiliations
- 1 Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. w.vanrheenen-2@umcutrecht.nl.
- 2 Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
- 3 Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
- 4 Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
- 5 University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK.
- 6 Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.
- 7 Laboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, Belgium.
- 8 Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
- 9 Translational Biology, Biogen, Boston, MA, USA.
- 10 MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK.
- 11 Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
- 12 Illumina, San Diego, CA, USA.
- 13 Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
- 14 Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
- 15 Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 16 Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 17 National Institute for Health Research Biomedical Research Centre and Dementia Unit, South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
- 18 Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.
- 19 Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy.
- 20 Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
- 21 Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
- 22 Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.
- 23 UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
- 24 School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
- 25 Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
- 26 Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
- 27 Institute of Clinical Neurobiology, University Hospital Würzburg, Würzburg, Germany.
- 28 Charité University Hospital, Humboldt University, Berlin, Germany.
- 29 Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey.
- 30 Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands.
- 31 Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy.
- 32 Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.
- 33 3rd Neurology Unit, Motor Neuron Diseases Center, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', MIlan, Italy.
- 34 Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
- 35 Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
- 36 Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy.
- 37 Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
- 38 Department of Neurosciences, University of Padova, Padova, Italy.
- 39 Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
- 40 Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
- 41 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.
- 42 Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.
- 43 Laboratory of Neurological Diseases, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
- 44 Department of Clinical Research in Neurology, University of Bari at 'Pia Fondazione Card G. Panico' Hospital, Bari, Italy.
- 45 Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
- 46 Department of Neurology, Hannover Medical School, Hannover, Germany.
- 47 Essener Zentrum für Seltene Erkrankungen (EZSE), University Hospital Essen, Essen, Germany.
- 48 Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden.
- 49 Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
- 50 Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel.
- 51 Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
- 52 Department of Neurology, Neuromuscular Division, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
- 53 Service de Biochimie et Biologie Moléculaire, CHU de Tours, Tours, France.
- 54 UMR 1253, Université de Tours, Inserm, Tours, France.
- 55 Centre de référence sur la SLA, CHU de Tours, Tours, France.
- 56 Centre de référence sur la SLA, CHRU de Limoges, Limoges, France.
- 57 UMR 1094, Université de Limoges, Inserm, Limoges, France.
- 58 ICM, Institut du Cerveau, Inserm, CNRS, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France.
- 59 Hôpital des Peupliers, Ramsay Générale de Santé, Paris, France.
- 60 Département de Neurologie, Centre de référence SLA Ile de France, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
- 61 ALS Unit, Hospital San Rafael, Madrid, Spain.
- 62 Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.
- 63 MND Clinic, Neurology Department, Hospital de la Santa Creu i Sant Pau de Barcelona, Universitat Autonoma de Barcelona, Barcelona, Spain.
- 64 Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
- 65 Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
- 66 Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
- 67 Department of Neurology, Ulm University, Ulm, Germany.
- 68 Division of Neurodegeneration, Department of Neurology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
- 69 German Center for Neurodegenerative Diseases (DZNE) Ulm, Ulm, Germany.
- 70 Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, UPMC Pharmacologie, AP-HP, Paris, France.
- 71 Pharmacologie Sorbonne Université, Paris, France.
- 72 Institut du Cerveau, Paris Brain Institute ICM, Paris, France.
- 73 Laboratoire de Biostatistique, Epidémiologie Clinique, Santé Publique Innovation et Méthodologie (BESPIM), CHU-Nîmes, Nîmes, France.
- 74 Sorbonne Université, Paris Brain Institute, APHP, INSERM, CNRS, Hôpital de la Pitié Salpêtrière, Paris, France.
- 75 Genethon, CNRS UMR, Evry, France.
- 76 Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.
- 77 Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA.
- 78 Popgen Biobank and Institute of Epidemiology, Christian Albrechts-University Kiel, Kiel, Germany.
- 79 Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
- 80 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
- 81 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 82 Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
- 83 Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
- 84 Department of Internal Medicine, Genetics Laboratory, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
- 85 Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
- 86 Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
- 87 Central Institute of Mental Health, Mannheim, Germany.
- 88 Institute of Human Genetics, University of Bonn, Bonn, Germany.
- 89 Department of Genomics, Life and Brain Center, Bonn, Germany.
- 90 Division of Medical Genetics, University Hospital Basel and Department of Biomedicine, University of Basel, Basel, Switzerland.
- 91 Institute of Neuroscience and Medicine INM-1, Research Center Juelich, Juelich, Germany.
- 92 INSERM UMR1167-RID-AGE LabEx DISTALZ-Risk Factors and Molecular Determinants of Aging-Related Diseases, University of Lille, Centre Hospitalier of the University of Lille, Institut Pasteur de Lille, Lille, France.
- 93 Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA.
- 94 Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
- 95 Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA.
- 96 Universidade de São Paulo, São Paulo, Brazil.
- 97 Centre for Molecular Medicine and Biobanking and Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
- 98 University Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.
- 99 Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
- 100 Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
- 101 Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
- 102 Department of Neurology, University of California, San Francisco, CA, USA.
- 103 Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
- 104 Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.
- 105 Precision Neurology Unit, Department of Neurology, University Hospital Schleswig-Holstein, University of Luebeck, Luebeck, Germany.
- 106 Institute of Human Genetics, Jena University Hospital, Jena, Germany.
- 107 Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.
- 108 Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia.
- 109 Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russia.
- 110 Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia.
- 111 ALS-Care Center, 'GAOORDI', Medical Clinic of the St. Petersburg, St. Petersburg, Russia.
- 112 Department of Biotechnology, Jožef Stefan Institute, Ljubljana, Slovenia.
- 113 Biomedical Research Institute BRIS, Ljubljana, Slovenia.
- 114 Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.
- 115 Ljubljana ALS Centre, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
- 116 Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
- 117 Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
- 118 Clinic of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
- 119 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
- 120 Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
- 121 Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
- 122 Australian Centre for Precision Health and Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.
- 123 Centre for Clinical Research, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.
- 124 Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
- 125 Calvary Health Care Bethlehem, Parkdale, Victoria, Australia.
- 126 Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
- 127 Fiona Stanley Hospital, Perth, Western Australia, Australia.
- 128 Notre Dame University, Fremantle, Western Australia, Australia.
- 129 Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.
- 130 Northcott Neuroscience Laboratory, ANZAC Research Institute, Concord, New South Wales, Australia.
- 131 Molecular Medicine Laboratory, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
- 132 Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
- 133 The School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
- 134 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
- 135 Neuroscience Research Australia Institute, Randwick, New South Wales, Australia.
- 136 Neuropsychiatric Institute, the Prince of Wales Hospital, UNSW, Randwick, New South Wales, Australia.
- 137 Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St. Gallen, St. Gallen, Switzerland.
- 138 Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
- 139 NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
- 140 Department Neurology, Emory University School of Medicine, Atlanta, GA, USA.
- 141 Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.
- 142 Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
- 143 Department of Neurology, Third Hospital, Peking University, Beijing, China.
- 144 Population Health Science, Bristol Medical School, Bristol, UK.
- 145 King's College Hospital, London, UK.
- 146 Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. j.h.veldink@umcutrecht.nl.
# Contributed equally.
- PMID: 35102318
- PMCID: PMC8920884
- DOI: 10.1038/s41588-022-01020-3
Item in Clipboard
Published Erratum
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Wouter van Rheenen et al.
Nat Genet.
2022 Mar.
Display options
Format
doi: 10.1038/s41588-022-01020-3.
Authors
Wouter van Rheenen #
1
, Rick A A van der Spek #
2
, Mark K Bakker #
2
, Joke J F A van Vugt
2
, Paul J Hop
2
, Ramona A J Zwamborn
2
, Niek de Klein
3
, Harm-Jan Westra
3
, Olivier B Bakker
3
, Patrick Deelen
3
4
, Gemma Shireby
5
, Eilis Hannon
5
, Matthieu Moisse
6
7
8
, Denis Baird
9
10
, Restuadi Restuadi
11
, Egor Dolzhenko
12
, Annelot M Dekker
2
, Klara Gawor
2
, Henk-Jan Westeneng
2
, Gijs H P Tazelaar
2
, Kristel R van Eijk
2
, Maarten Kooyman
2
, Ross P Byrne
13
, Mark Doherty
13
, Mark Heverin
14
, Ahmad Al Khleifat
15
, Alfredo Iacoangeli
15
16
17
, Aleksey Shatunov
15
, Nicola Ticozzi
18
19
, Johnathan Cooper-Knock
20
, Bradley N Smith
15
, Marta Gromicho
21
, Siddharthan Chandran
22
23
, Suvankar Pal
22
23
, Karen E Morrison
24
, Pamela J Shaw
20
, John Hardy
25
, Richard W Orrell
26
, Michael Sendtner
27
, Thomas Meyer
28
, Nazli Başak
29
, Anneke J van der Kooi
30
, Antonia Ratti
18
31
, Isabella Fogh
15
, Cinzia Gellera
32
, Giuseppe Lauria
33
34
, Stefania Corti
19
35
, Cristina Cereda
36
, Daisy Sproviero
36
, Sandra D'Alfonso
37
, Gianni Sorarù
38
, Gabriele Siciliano
39
, Massimiliano Filosto
40
, Alessandro Padovani
40
, Adriano Chiò
41
42
, Andrea Calvo
41
42
, Cristina Moglia
41
42
, Maura Brunetti
41
, Antonio Canosa
41
42
, Maurizio Grassano
41
, Ettore Beghi
43
, Elisabetta Pupillo
43
, Giancarlo Logroscino
44
, Beatrice Nefussy
45
, Alma Osmanovic
46
47
, Angelica Nordin
48
, Yossef Lerner
49
50
, Michal Zabari
49
50
, Marc Gotkine
49
50
, Robert H Baloh
51
52
, Shaughn Bell
51
52
, Patrick Vourc'h
53
54
, Philippe Corcia
54
55
, Philippe Couratier
56
57
, Stéphanie Millecamps
58
, Vincent Meininger
59
, François Salachas
58
60
, Jesus S Mora Pardina
61
, Abdelilah Assialioui
62
, Ricardo Rojas-García
63
, Patrick A Dion
64
65
, Jay P Ross
64
66
, Albert C Ludolph
67
, Jochen H Weishaupt
68
, David Brenner
68
, Axel Freischmidt
67
69
, Gilbert Bensimon
70
71
72
73
, Alexis Brice
74
, Alexandra Durr
74
, Christine A M Payan
70
, Safa Saker-Delye
75
, Nicholas W Wood
76
, Simon Topp
15
, Rosa Rademakers
77
, Lukas Tittmann
78
, Wolfgang Lieb
78
, Andre Franke
79
, Stephan Ripke
80
81
82
, Alice Braun
82
, Julia Kraft
82
, David C Whiteman
83
, Catherine M Olsen
83
, Andre G Uitterlinden
84
85
, Albert Hofman
85
, Marcella Rietschel
86
87
, Sven Cichon
88
89
90
91
, Markus M Nöthen
88
89
, Philippe Amouyel
92
; SLALOM Consortium; PARALS Consortium; SLAGEN Consortium; SLAP Consortium; Bryan J Traynor
93
94
, Andrew B Singleton
95
, Miguel Mitne Neto
96
, Ruben J Cauchi
97
, Roel A Ophoff
98
99
100
, Martina Wiedau-Pazos
101
, Catherine Lomen-Hoerth
102
, Vivianna M van Deerlin
103
, Julian Grosskreutz
104
105
, Annekathrin Roediger
104
, Nayana Gaur
104
, Alexander Jörk
104
, Tabea Barthel
104
, Erik Theele
104
, Benjamin Ilse
104
, Beatrice Stubendorff
104
, Otto W Witte
104
, Robert Steinbach
104
, Christian A Hübner
106
, Caroline Graff
107
, Lev Brylev
108
109
110
, Vera Fominykh
108
110
, Vera Demeshonok
111
, Anastasia Ataulina
108
, Boris Rogelj
112
113
114
, Blaž Koritnik
115
, Janez Zidar
115
, Metka Ravnik-Glavač
116
, Damjan Glavač
117
, Zorica Stević
118
, Vivian Drory
45
119
, Monica Povedano
62
, Ian P Blair
120
, Matthew C Kiernan
121
, Beben Benyamin
11
122
, Robert D Henderson
123
124
, Sarah Furlong
120
, Susan Mathers
125
, Pamela A McCombe
124
126
, Merrilee Needham
127
128
129
, Shyuan T Ngo
123
124
126
, Garth A Nicholson
120
130
131
, Roger Pamphlett
132
, Dominic B Rowe
120
, Frederik J Steyn
124
133
, Kelly L Williams
120
, Karen A Mather
134
135
, Perminder S Sachdev
134
136
, Anjali K Henders
11
, Leanne Wallace
11
, Mamede de Carvalho
21
, Susana Pinto
21
, Susanne Petri
46
, Markus Weber
137
, Guy A Rouleau
64
65
66
, Vincenzo Silani
18
19
, Charles J Curtis
138
139
, Gerome Breen
138
139
, Jonathan D Glass
140
, Robert H Brown Jr
141
, John E Landers
141
, Christopher E Shaw
15
, Peter M Andersen
48
, Ewout J N Groen
2
, Michael A van Es
2
, R Jeroen Pasterkamp
142
, Dongsheng Fan
143
, Fleur C Garton
11
, Allan F McRae
11
, George Davey Smith
10
144
, Tom R Gaunt
10
144
, Michael A Eberle
12
, Jonathan Mill
5
, Russell L McLaughlin
13
, Orla Hardiman
14
, Kevin P Kenna
2
142
, Naomi R Wray
11
126
, Ellen Tsai
9
, Heiko Runz
9
, Lude Franke
3
, Ammar Al-Chalabi
15
145
, Philip Van Damme
6
7
8
, Leonard H van den Berg
2
, Jan H Veldink
146
Collaborators
-
Giancarlo Comi, Nilo Riva, Christian Lunetta, Francesca Gerardi, Maria Sofia Cotelli, Fabrizio Rinaldi, Luca Chiveri, Maria Cristina Guaita, Patrizia Perrone, Mauro Ceroni, Luca Diamanti, Carlo Ferrarese, Lucio Tremolizzo, Maria Luisa Delodovici, Giorgio Bono, Antonio Canosa, Umberto Manera, Rosario Vasta, Alessandro Bombaci, Federico Casale, Giuseppe Fuda, Paolina Salamone, Barbara Iazzolino, Laura Peotta, Paolo Cugnasco, Giovanni De Marco, Maria Claudia Torrieri, Francesca Palumbo, Salvatore Gallone, Marco Barberis, Luca Sbaiz, Salvatore Gentile, Alessandro Mauro, Letizia Mazzini, Fabiola De Marchi, Lucia Corrado, Sandra D'Alfonso, Antonio Bertolotto, Maurizio Gionco, Daniela Leotta, Enrico Odddenino, Daniele Imperiale, Roberto Cavallo, Pietro Pignatta, Marco De Mattei, Claudio Geda, Diego Maria Papurello, Graziano Gusmaroli, Cristoforo Comi, Carmelo Labate, Luigi Ruiz, Delfina Ferrandi, Eugenia Rota, Marco Aguggia, Nicoletta Di Vito, Piero Meineri, Paolo Ghiglione, Nicola Launaro, Michele Dotta, Alessia Di Sapio, Guido Giardini, Cinzia Tiloca, Silvia Peverelli, Franco Taroni, Viviana Pensato, Barbara Castellotti, Giacomo P Comi, Roberto Del Bo, Mauro Ceroni, Stella Gagliardi, Lucia Corrado, Letizia Mazzini, Flavia Raggi, Costanza Simoncini, Annalisa Lo Gerfo, Maurizio Inghilleri, Alessandra Ferlini, Isabella L Simone, Bruno Passarella, Vito Guerra, Stefano Zoccolella, Cecilia Nozzoli, Ciro Mundi, Maurizio Leone, Michele Zarrelli, Filippo Tamma, Francesco Valluzzi, Gianluigi Calabrese, Giovanni Boero, Augusto Rini
Affiliations
- 1 Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. w.vanrheenen-2@umcutrecht.nl.
- 2 Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
- 3 Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
- 4 Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
- 5 University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK.
- 6 Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.
- 7 Laboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, Belgium.
- 8 Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
- 9 Translational Biology, Biogen, Boston, MA, USA.
- 10 MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK.
- 11 Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
- 12 Illumina, San Diego, CA, USA.
- 13 Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
- 14 Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
- 15 Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 16 Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 17 National Institute for Health Research Biomedical Research Centre and Dementia Unit, South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
- 18 Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.
- 19 Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy.
- 20 Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
- 21 Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
- 22 Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.
- 23 UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
- 24 School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
- 25 Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
- 26 Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
- 27 Institute of Clinical Neurobiology, University Hospital Würzburg, Würzburg, Germany.
- 28 Charité University Hospital, Humboldt University, Berlin, Germany.
- 29 Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey.
- 30 Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands.
- 31 Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy.
- 32 Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.
- 33 3rd Neurology Unit, Motor Neuron Diseases Center, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', MIlan, Italy.
- 34 Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
- 35 Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
- 36 Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy.
- 37 Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
- 38 Department of Neurosciences, University of Padova, Padova, Italy.
- 39 Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
- 40 Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
- 41 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.
- 42 Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.
- 43 Laboratory of Neurological Diseases, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
- 44 Department of Clinical Research in Neurology, University of Bari at 'Pia Fondazione Card G. Panico' Hospital, Bari, Italy.
- 45 Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
- 46 Department of Neurology, Hannover Medical School, Hannover, Germany.
- 47 Essener Zentrum für Seltene Erkrankungen (EZSE), University Hospital Essen, Essen, Germany.
- 48 Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden.
- 49 Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
- 50 Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel.
- 51 Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
- 52 Department of Neurology, Neuromuscular Division, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
- 53 Service de Biochimie et Biologie Moléculaire, CHU de Tours, Tours, France.
- 54 UMR 1253, Université de Tours, Inserm, Tours, France.
- 55 Centre de référence sur la SLA, CHU de Tours, Tours, France.
- 56 Centre de référence sur la SLA, CHRU de Limoges, Limoges, France.
- 57 UMR 1094, Université de Limoges, Inserm, Limoges, France.
- 58 ICM, Institut du Cerveau, Inserm, CNRS, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France.
- 59 Hôpital des Peupliers, Ramsay Générale de Santé, Paris, France.
- 60 Département de Neurologie, Centre de référence SLA Ile de France, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
- 61 ALS Unit, Hospital San Rafael, Madrid, Spain.
- 62 Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.
- 63 MND Clinic, Neurology Department, Hospital de la Santa Creu i Sant Pau de Barcelona, Universitat Autonoma de Barcelona, Barcelona, Spain.
- 64 Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
- 65 Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
- 66 Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
- 67 Department of Neurology, Ulm University, Ulm, Germany.
- 68 Division of Neurodegeneration, Department of Neurology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
- 69 German Center for Neurodegenerative Diseases (DZNE) Ulm, Ulm, Germany.
- 70 Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, UPMC Pharmacologie, AP-HP, Paris, France.
- 71 Pharmacologie Sorbonne Université, Paris, France.
- 72 Institut du Cerveau, Paris Brain Institute ICM, Paris, France.
- 73 Laboratoire de Biostatistique, Epidémiologie Clinique, Santé Publique Innovation et Méthodologie (BESPIM), CHU-Nîmes, Nîmes, France.
- 74 Sorbonne Université, Paris Brain Institute, APHP, INSERM, CNRS, Hôpital de la Pitié Salpêtrière, Paris, France.
- 75 Genethon, CNRS UMR, Evry, France.
- 76 Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.
- 77 Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA.
- 78 Popgen Biobank and Institute of Epidemiology, Christian Albrechts-University Kiel, Kiel, Germany.
- 79 Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
- 80 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
- 81 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 82 Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
- 83 Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
- 84 Department of Internal Medicine, Genetics Laboratory, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
- 85 Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
- 86 Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
- 87 Central Institute of Mental Health, Mannheim, Germany.
- 88 Institute of Human Genetics, University of Bonn, Bonn, Germany.
- 89 Department of Genomics, Life and Brain Center, Bonn, Germany.
- 90 Division of Medical Genetics, University Hospital Basel and Department of Biomedicine, University of Basel, Basel, Switzerland.
- 91 Institute of Neuroscience and Medicine INM-1, Research Center Juelich, Juelich, Germany.
- 92 INSERM UMR1167-RID-AGE LabEx DISTALZ-Risk Factors and Molecular Determinants of Aging-Related Diseases, University of Lille, Centre Hospitalier of the University of Lille, Institut Pasteur de Lille, Lille, France.
- 93 Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA.
- 94 Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
- 95 Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA.
- 96 Universidade de São Paulo, São Paulo, Brazil.
- 97 Centre for Molecular Medicine and Biobanking and Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
- 98 University Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.
- 99 Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
- 100 Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
- 101 Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
- 102 Department of Neurology, University of California, San Francisco, CA, USA.
- 103 Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
- 104 Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.
- 105 Precision Neurology Unit, Department of Neurology, University Hospital Schleswig-Holstein, University of Luebeck, Luebeck, Germany.
- 106 Institute of Human Genetics, Jena University Hospital, Jena, Germany.
- 107 Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.
- 108 Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia.
- 109 Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russia.
- 110 Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia.
- 111 ALS-Care Center, 'GAOORDI', Medical Clinic of the St. Petersburg, St. Petersburg, Russia.
- 112 Department of Biotechnology, Jožef Stefan Institute, Ljubljana, Slovenia.
- 113 Biomedical Research Institute BRIS, Ljubljana, Slovenia.
- 114 Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.
- 115 Ljubljana ALS Centre, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
- 116 Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
- 117 Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
- 118 Clinic of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
- 119 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
- 120 Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
- 121 Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
- 122 Australian Centre for Precision Health and Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.
- 123 Centre for Clinical Research, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.
- 124 Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
- 125 Calvary Health Care Bethlehem, Parkdale, Victoria, Australia.
- 126 Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
- 127 Fiona Stanley Hospital, Perth, Western Australia, Australia.
- 128 Notre Dame University, Fremantle, Western Australia, Australia.
- 129 Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia.
- 130 Northcott Neuroscience Laboratory, ANZAC Research Institute, Concord, New South Wales, Australia.
- 131 Molecular Medicine Laboratory, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
- 132 Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
- 133 The School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
- 134 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
- 135 Neuroscience Research Australia Institute, Randwick, New South Wales, Australia.
- 136 Neuropsychiatric Institute, the Prince of Wales Hospital, UNSW, Randwick, New South Wales, Australia.
- 137 Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St. Gallen, St. Gallen, Switzerland.
- 138 Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
- 139 NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
- 140 Department Neurology, Emory University School of Medicine, Atlanta, GA, USA.
- 141 Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.
- 142 Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
- 143 Department of Neurology, Third Hospital, Peking University, Beijing, China.
- 144 Population Health Science, Bristol Medical School, Bristol, UK.
- 145 King's College Hospital, London, UK.
- 146 Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. j.h.veldink@umcutrecht.nl.
# Contributed equally.
- PMID: 35102318
- PMCID: PMC8920884
- DOI: 10.1038/s41588-022-01020-3
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Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra HJ, Bakker OB, Deelen P, Shireby G, Hannon E, Moisse M, Baird D, Restuadi R, Dolzhenko E, Dekker AM, Gawor K, Westeneng HJ, Tazelaar GHP, van Eijk KR, Kooyman M, Byrne RP, Doherty M, Heverin M, Al Khleifat A, Iacoangeli A, Shatunov A, Ticozzi N, Cooper-Knock J, Smith BN, Gromicho M, Chandran S, Pal S, Morrison KE, Shaw PJ, Hardy J, Orrell RW, Sendtner M, Meyer T, Başak N, van der Kooi AJ, Ratti A, Fogh I, Gellera C, Lauria G, Corti S, Cereda C, Sproviero D, D'Alfonso S, Sorarù G, Siciliano G, Filosto M, Padovani A, Chiò A, Calvo A, Moglia C, Brunetti M, Canosa A, Grassano M, Beghi E, Pupillo E, Logroscino G, Nefussy B, Osmanovic A, Nordin A, Lerner Y, Zabari M, Gotkine M, Baloh RH, Bell S, Vourc'h P, Corcia P, Couratier P, Millecamps S, Meininger V, Salachas F, Mora Pardina JS, Assialioui A, Rojas-García R, Dion PA, Ross JP, Ludolph AC, Weishaupt JH, Brenner D, Freischmidt A, Bensimon G, Brice A, Durr A, Payan CAM, Saker-Delye S, Wood NW, Topp S, Rademakers R, Tittmann L, Lieb W, Franke A, Ripke S, Braun A, Kraft J, Whiteman DC, Olsen CM, Uitterlinden AG, Hofman A, Rietschel M, Cich… See abstract for full author list ➔ van Rheenen W, et al. Nat Genet. 2021 Dec;53(12):1636-1648. doi: 10.1038/s41588-021-00973-1. Epub 2021 Dec 6. Nat Genet. 2021. PMID: 34873335 Free PMC article.
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