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. 2022 Jan 18;3(1):100490.
doi: 10.1016/j.xcrm.2021.100490.

Potential role of neurofilament in COVID-19 and preeclampsia

Athina Samara  1   2 , Eric Herlenius  1   2 , Patrick O' Brien  3   4 , Asma Khalil  5   6   7
Affiliations

Potential role of neurofilament in COVID-19 and preeclampsia

Athina Samara et al. Cell Rep Med. .

Abstract

Neurofilament light (NFL) is a promising circulating biomarker in preeclampsia and COVID-19, even without evident neurological complications. Several pathways might contribute to the elevated serum NFL levels seen in both pathologies. Future studies will determine whether NFL is a long COVID marker and delineate NFL's role in COVID-19-associated preeclampsia.

Keywords: COVID-19; SARS-CoV-2; hypertension; long COVID; neurofilament; preeclampsia; pregnancy; sNFL.

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Figures

Figure 1
Figure 1
Published and suggested mechanisms of induction and secretion of sNFL that might be contributing to the elevated maternal levels of NFL seen in preeclampsia and COVID-19 Cellular origin of neurofilament during neurogenesis and placental development and mechanistic similarities among the two pathologies are highlighted, indicating physiological sources of sNFL and ectopic expression and release. CSF, cerebrospinal fluid; BBB, blood-brain barrier; MSC, mesenchymal stem cell; HIF-1, hypoxia-inducible factor 1, NEUROD1, neurogenic differentiation 1; hCG, human chorionic gonadotropin; UC, umbilical cord.
Figure 2
Figure 2
A summary of the known NFL release and suggested NFL ectopic expression mechanisms in COVID-19 and preeclampsia
See this image and copyright information in PMC

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