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. 2022 Jan;16(1):55-59.
doi: 10.22074/IJFS.2021.522861.1073.

Evaluation of Levels of Advanced Oxidative Protein Products in Patients with Polycystic Ovary Syndrome with and without Chronic Periodontitis: A Cross-Sectional Study

Smriti Dharuman  1 , Supraja Ajith Kumar  1 , Subbusamy Kanakasabapathy Balaji  1 , Usha Vishwanath  2 , Royapuram Parthasarathy Parameshwari  3 , Muthukumar Santhanakrishnan  4
Affiliations

Evaluation of Levels of Advanced Oxidative Protein Products in Patients with Polycystic Ovary Syndrome with and without Chronic Periodontitis: A Cross-Sectional Study

Smriti Dharuman et al. Int J Fertil Steril. 2022 Jan.

Abstract

Polycystic ovary syndrome (PCOS) is a common condition with a multifactorial aetiology. Chronic periodontitis (CP) is an immunoinflammatory disease that is linked to PCOS via the excessive production of reactive oxygen species (ROS), which leads to an imbalance in the antioxidant system. However, limited studies have evaluated the relationship between these diseases. The current study aims to evaluate the levels of advanced oxidation protein products (AOPP) in patients with periodontitis and PCOS. Four groups, each consisting of 12 patients, with both PCOS and CP (PCOSCP), systemically healthy women with CP, periodontally healthy women with PCOS (PCOSPH), and periodontally and systemically healthy women (PH) were included in the study. Clinical parameters such as clinical attachment loss, bleeding on probing (BOP), and periodontal inflamed surface area (PISA) index were noted. AOPP were evaluated in the saliva and serum samples by spectrophotometric detection. Salivary and serum AOPP levels were highest in the PCOSCP group (75.16 ± 7.50 μmol/l, 97.92 ± 6.50 μmol/l, respectively). Statistical significance (P<0.05) was noted between the salivary AOPP levels of the PCOSCP group and PCOS group. PISA was greatest in the PCOSCP group (1338.40 ± 285.96 mm2 ) followed by the PCOS group (680.33 ± 79.49 mm2 ), which showed the impact of PCOS on gingival inflammation. According to the results of this study, increased levels of advanced oxidative protein products appeared to show the effect of CP on worsening PCOS.

Keywords: Gingivitis; Oxidative Stress; Reactive Oxygen Species.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Fig.1
Fig.1
Graph showing the PISA scores. Lines connecting the bars indicate a statistical significant difference P<0.05. PISA; Periodontal inflamed surface area and PCOSCP; Polycystic ovary syndrome and chronic periodontitis.
Fig.2
Fig.2
Graph showing the AOPP serum levels. Lines connecting the bars indicate a statistical significant difference P<0.05. PISA; Periodontal inflamed surface area and PCOSCP; Polycystic ovary syndrome and chronic periodontitis.
Fig.3
Fig.3
Graph showing the AOPP levels in saliva. Lines connecting the bars indicate a statistical significant difference P<0.05. PISA; Periodontal inflamed surface area and PCOSCP; Polycystic ovary syndrome and chronic periodontitis.
See this image and copyright information in PMC

References

    1. Stein IF Sr. The Stein-Leventhal syndrome; a curable form of sterility. N Engl J Med. 1958;259(9):420–423. - PubMed
    1. Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Periodontol. 2018;89(Suppl 1):S159–S172. - PubMed
    1. Liu C, Mo L, Niu Y, Li X, Zhou X, Xu X. The role of reactive oxygen species and autophagy in periodontitis and their potential linkage. Front Physiol. 2017;8:439–439. - PMC - PubMed
    1. Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D’Aiuto F, Bouchard P, et al. Periodontitis and cardiovascular diseases: consensus report. J Clin Periodontol. 2020;47(3):268–288. - PMC - PubMed
    1. Potempa J, Mydel P, Koziel J. The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol. 2017;13(10):606–620. - PubMed

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