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. 2022 Mar:128:108536.
doi: 10.1016/j.yebeh.2021.108536. Epub 2022 Jan 1.

Impact of the COVID-19 pandemic on persons with epilepsy in Uganda: A descriptive cross-sectional study

Nolbert Gumisiriza  1 , Olivia Kamoen  2 , Annelies Boven  3 , Alfred Dusabimana  3 , Denis Nono  4 , Seggane Musisi  5 , Robert Colebunders  6
Affiliations

Impact of the COVID-19 pandemic on persons with epilepsy in Uganda: A descriptive cross-sectional study

Nolbert Gumisiriza et al. Epilepsy Behav. 2022 Mar.

Abstract

Objective: To evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on the disease course, lives, and psychosocial wellbeing of persons with epilepsy (PWE) in Uganda.

Methods: From April 2021 till May 2021, we carried out a descriptive cross-sectional study at four hospitals located in four regions of Uganda. PWE presenting at the study sites were offered a structured questionnaire in the local language. We used the PHQ-9 questionnaire to screen for depression and the GAD-7 to screen for anxiety. Univariate and multivariable logistic regression was used to investigate factors associated with anxiety and depression.

Results: A total of 370 responses were collected. The median age of the respondents was 20.5 years (IQR 15-29), and 51.9% were males. During the lockdown period, the seizure frequency increased in 87 (23.5%) PWE. Various forms of physical and psychological violence were inflicted upon 106 (28.6%) PWE. Fifty-eight (15.7%) screened positive for anxiety and 65 (17.6%) positive for depression. Both increased seizure frequency and experienced violence were associated with experiencing depression and anxiety.

Conclusion: The COVID-19 pandemic and lockdown impacted seizure frequency and the psychosocial wellbeing of PWE in Uganda. Increased seizure frequency was associated with higher rates of anxiety and depression. This underlines the importance of continued follow-up of PWE and a low threshold to screen for depression, anxiety, and domestic violence.

Keywords: Anxiety; COVID-19; Depression; Epilepsy; Lockdown; Uganda.

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Figures

Fig. 1
Fig. 1
Map of Uganda showing the location of the four study sites (Butabika, Mbale, Kabale, and Kitgum).
Fig. 2
Fig. 2
Histogram showing the distribution of persons with epilepsy in Uganda who experienced violence during the COVID-19 lockdown by age and gender.
See this image and copyright information in PMC

References

    1. WHO. Epilepsy 2019. https://www.who.int/news-room/fact-sheets/detail/epilepsy (accessed September 23, 2021).
    1. Fiest K.M., Sauro K.M., Wiebe S., Patten S.B., Kwon C.-S., Dykeman J., et al. Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies. Neurology. 2017;88:296–303. doi: 10.1212/WNL.0000000000003509. - DOI - PMC - PubMed
    1. Velavan T.P., Meyer C.G. The COVID-19 epidemic. Trop Med Int Health. 2020;25:278–280. doi: 10.1111/tmi.13383. - DOI - PMC - PubMed
    1. Ministry of Health. COVID-19 Uganda. COVID-19 Minist Health 2021. https://www.health.go.ug/covid/ (accessed November 3, 2021).
    1. New Vision. President Museveni to lift lockdown. New Vis 2021. https://www.newvision.co.ug/articledetails/110508 (accessed September 22, 2021).

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