Back to the Future: Esmethadone, the (Maybe) Nonopiate Opiate, and Depression

Affiliations

Editorial

Charles B Nemeroff. Am J Psychiatry. 2022 Feb.

. 2022 Feb;179(2):83-84.

doi: 10.1176/appi.ajp.2021.21121204.

¹ Department of Psychiatry and Behavioral Sciences, University of Texas at Austin, Dell Medical School.

No abstract available

Keywords: Depressive Disorders; Psychopharmacology.

Comment on

REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial.
Fava M, Stahl S, Pani L, De Martin S, Pappagallo M, Guidetti C, Alimonti A, Bettini E, Mangano RM, Wessel T, de Somer M, Caron J, Vitolo OV, DiGuglielmo GR, Gilbert A, Mehta H, Kearney M, Mattarei A, Gentilucci M, Folli F, Traversa S, Inturrisi CE, Manfredi PL. Fava M, et al. Am J Psychiatry. 2022 Feb;179(2):122-131. doi: 10.1176/appi.ajp.2021.21020197. Epub 2021 Dec 22. Am J Psychiatry. 2022. PMID: 34933568 Clinical Trial.