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Comment
. 2022 Jan 18;3(1):100505.
doi: 10.1016/j.xcrm.2021.100505.

Are changes in the gut microbiome a contributor or consequence of autism-why not both?

Ezgi Özcan  1 , Elaine Y Hsiao  1
Affiliations
Comment

Are changes in the gut microbiome a contributor or consequence of autism-why not both?

Ezgi Özcan et al. Cell Rep Med. .

Abstract

Alterations in the gut microbiome have been associated with autism spectrum disorder (ASD), but whether they are a cause, effect, or confounder remains unclear. In a recent issue of Cell, Yap and colleagues report that ASD-associated microbiota changes are likely a consequence of low diet diversity.1.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Potential interactions between the gut microbiome and ASD Yap and colleagues reveal that autistic traits are associated with decreases in diet diversity, which likely drives microbiome alterations and loose stool consistency observed in individuals diagnosed with ASD. Still unclear are whether the gut microbiome could contribute to or modify risk for the early development of ASD, and whether the ASD-driven changes in the gut microbiome in later life could influence the severity of symptoms of disease.
See this image and copyright information in PMC

Comment on

  • Autism-related dietary preferences mediate autism-gut microbiome associations.
    Yap CX, Henders AK, Alvares GA, Wood DLA, Krause L, Tyson GW, Restuadi R, Wallace L, McLaren T, Hansell NK, Cleary D, Grove R, Hafekost C, Harun A, Holdsworth H, Jellett R, Khan F, Lawson LP, Leslie J, Frenk ML, Masi A, Mathew NE, Muniandy M, Nothard M, Miller JL, Nunn L, Holtmann G, Strike LT, de Zubicaray GI, Thompson PM, McMahon KL, Wright MJ, Visscher PM, Dawson PA, Dissanayake C, Eapen V, Heussler HS, McRae AF, Whitehouse AJO, Wray NR, Gratten J. Yap CX, et al. Cell. 2021 Nov 24;184(24):5916-5931.e17. doi: 10.1016/j.cell.2021.10.015. Epub 2021 Nov 11. Cell. 2021. PMID: 34767757

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