MicroRNA: Crucial modulator in purinergic signalling involved diseases

Abstract

Both microRNAs (miRNAs) and purinergic signalling are widely and respectively expressed in various tissues of different organisms and play vital roles in a variety of physiological and pathological processes. Here, we reviewed the current publications contributed to the relationship of miRNAs and purinergic signalling in cardiovascular diseases, gastrointestinal diseases, neurological diseases, and ophthalmic diseases. We tried to decode the miRNAs-purinergic signalling network of purinergic signalling involved diseases. The evidence indicated that more than 30 miRNAs (miR-22, miR-30, miR-146, miR-150, miR-155, miR-187, etc.) directly or indirectly modulate P1 receptors (A₁, A_2A, A_2B, A₃), P2 receptors (P2X1, P2X3, P2X4, P2X7, P2Y2, P2Y6, P2Y12), and ecto-enzymes (CD39, CD73, ADA2); P2X7 and CD73 could be modulated by multiple miRNAs (P2X7: miR-21, miR-22, miR-30, miR-135a, miR-150, miR-186, miR-187, miR-216b; CD73: miR-141, miR-101, miR-193b, miR-340, miR-187, miR-30, miR-422a); miR-187 would be the common miRNA to modulate P2X7 and CD73.

Keywords: Cancers; Cardiovascular diseases; Gastrointestinal diseases; Musculoskeletal diseases; Neurological diseases; Ophthalmic diseases; Purinergic signalling; microRNAs.

Fig. 1

Interaction between purinergic signalling and miRNAs. The whole P1 receptor family (A₁, A_2A, A_2B, A₃) are correlated with miRNAs. Among the P2 receptor family, P2X1, P2X3, P2X4, P2X7, P2Y2, P2Y6, and P2Y12 were currently found to correlate with miRNAs. CD39, CD73, and ADA2 are modulated by miRNAs, as well. Typically, purinergic signalling is posttranscriptionally modulated by miRNAs (blue arrow). Intriguingly, some purinergic signalling modulates miRNAs in turn (green arrow), while part of them can modulate each other mutually (red two-way arrow). Apparently, miR-187 modulates multiple purinergic signalling, P2X7 receptors and CD73. A_2A, A_2B, P2X7 receptors, and CD73 are modulated by multiple miRNAs