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Review
. 2022 Jun;83(4):842-858.
doi: 10.1002/ddr.21921. Epub 2022 Feb 1.

Recent advancement in drug development of nitro(NO2 )-heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis

Cauê Benito Scarim  1 , Fernando Rogério Pavan  2
Affiliations
Review

Recent advancement in drug development of nitro(NO2 )-heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis

Cauê Benito Scarim et al. Drug Dev Res. 2022 Jun.

Abstract

Tuberculosis (TB) is an infectious disease caused predominantly by Mycobacterium tuberculosis (Mtb). It was responsible for approximately 1.4 million deaths worldwide in 2019. The lack of new drugs to treat drug-resistant strains is a principal factor for the slow rise in TB infections. Our aim is to aid the development of new TB treatments by describing improvements (last decade, 2011-2021) to nitro(NO2 )-based compounds that have shown activity or pharmacological properties (e.g., anti-proliferative, anti-kinetoplastid) against Mtb. For all compounds, we have included final correlations of minimum inhibitory concentrations against Mtb (H37 Rv).

Keywords: H37Rv strain; Mycobacterium tuberculosis; antimycobacterial; drug development; minimum inhibitory concentrations; new drugs; nitro compounds.

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References

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