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. 2022 Feb 23;20(8):1637-1641.
doi: 10.1039/d1ob02159a.

Photoswitchable inhibitors of human β-glucocerebrosidase

Maria Giulia Davighi  1 , Francesca Clemente  1 , Camilla Matassini  1 , Francesca Cardona  1   2 , Mogens Brøndsted Nielsen  3 , Andrea Goti  1   2 , Amelia Morrone  4 , Paolo Paoli  5 , Martina Cacciarini  1
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Photoswitchable inhibitors of human β-glucocerebrosidase

Maria Giulia Davighi et al. Org Biomol Chem. .

Abstract

Light-switchable inhibitors of the enzyme β-glucocerebrosidase (GCase) have been developed by anchoring a specific azasugar to a dihydroazulene or an azobenzene responsive moiety. Their inhibitory effect towards human GCase, before and after irradiation are reported, and the effect on thermal denaturation of recombinant GCase and cytotoxicity were studied on selected candidates.

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