Mental Health During Late Pregnancy and Postpartum in Mothers With and Without Type 1 Diabetes: The ENDIA Study

Madeleine Hall^{1

2}, Helena Oakey¹, Megan A S Penno¹, Kelly McGorm¹, Amanda J Anderson¹, Pat Ashwood¹, Peter G Colman³, Maria E Craig^{4

5}, Elizabeth A Davis⁶, Mark Harris^{7

8}, Leonard C Harrison⁹, Aveni Haynes⁶, Claire Morbey¹⁰, Richard O Sinnott¹¹, Georgia Soldatos^{12

13}, Peter J Vuillermin^{14

15}, John M Wentworth^{3

9}, Rebecca L Thomson¹, Jennifer J Couper^{1

2}; ENDIA Study Group.

Collaborators, Affiliations

Collaborators

ENDIA Study Group.:
Simon C Barry, Maria E Craig, Peter G Colman, Jennifer J Couper, Elizabeth A Davis, Mark Harris, Leonard C Harrison, Aveni Haynes, Ki Wook Kim, Grant Morahan, Helena Oakey, Megan A S Penno, William D Rawlinson, Richard O Sinnott, Georgia Soldatos, Rebecca L Thomson, Peter J Vuillermin, John M Wentworth, Amanda J Anderson, Pat Ashwood, James D Brown, William Hu, Dao Huynh, Kelly J McGorm, Kelly Watson, Yeon Park, Emma Hamilton-Williams, Sarah Beresford, Samantha Bertram, Debra Bezuidenhout, Susan Brandrick, Carlie Butterworth, Jacki Catteau, Nakita Clements, Kyana Gartrell, Helen Griffiths, Alison Gwiazdzinski, Candice Hall, Gail Harper, Amanda Hulley, Mikayla Hoffman, Renee Kludas, Christine Monagle, Belinda Moore, Benjamin Ramoso, Alison Roberts, Georgina Thompson, Alexandra Tully, Isabelle Vicary, Rosemary Wood, Rachel Battersby, Teela Jullie, Stephanie Savio, Esther Bandala Sanchez, Naiara Bediaga, Chris Hope, Tim Sadlon, Alexandra Roth Schulze, Sabrina Binkowski, Bek Brittain, Minh Bui, Dylan Foskett, Dexing Huang, Stuti Kapadia, Asma Minhaj, Gaetano Naselli, Katrina Ngui, Trung Nguyen, Emily Wood, Cynthia Yau, Leanne Cavenett

Affiliations

¹ Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
² Department of Diabetes and Endocrinology, Women's and Children's Hospital, Adelaide, South Australia, Australia.
³ Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
⁴ School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
⁵ Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
⁶ Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
⁷ The University of Queensland Diamantina Institute, Queensland, Australia.
⁸ Queensland Children's Hospital, South Brisbane, Queensland, Australia.
⁹ Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
¹⁰ Hunter Diabetes Centre, Merewether, New South Wales, Australia.
¹¹ Melbourne eResearch Group, School of Computing and Information Services, University of Melbourne, Melbourne, Victoria, Australia.
¹² Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
¹³ Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Victoria, Australia.
¹⁴ Faculty of Health, School of Medicine, Deakin University, Geelong, Victoria, Australia.
¹⁵ Child Health Research Unit, Barwon Health, Geelong, Victoria, Australia.

PMID: 35107582
DOI: 10.2337/dc21-2335

Mental Health During Late Pregnancy and Postpartum in Mothers With and Without Type 1 Diabetes: The ENDIA Study

Madeleine Hall et al. Diabetes Care. 2022.

. 2022 Feb 2:dc212335.

doi: 10.2337/dc21-2335. Online ahead of print.

Authors

Collaborators

ENDIA Study Group.:
Simon C Barry, Maria E Craig, Peter G Colman, Jennifer J Couper, Elizabeth A Davis, Mark Harris, Leonard C Harrison, Aveni Haynes, Ki Wook Kim, Grant Morahan, Helena Oakey, Megan A S Penno, William D Rawlinson, Richard O Sinnott, Georgia Soldatos, Rebecca L Thomson, Peter J Vuillermin, John M Wentworth, Amanda J Anderson, Pat Ashwood, James D Brown, William Hu, Dao Huynh, Kelly J McGorm, Kelly Watson, Yeon Park, Emma Hamilton-Williams, Sarah Beresford, Samantha Bertram, Debra Bezuidenhout, Susan Brandrick, Carlie Butterworth, Jacki Catteau, Nakita Clements, Kyana Gartrell, Helen Griffiths, Alison Gwiazdzinski, Candice Hall, Gail Harper, Amanda Hulley, Mikayla Hoffman, Renee Kludas, Christine Monagle, Belinda Moore, Benjamin Ramoso, Alison Roberts, Georgina Thompson, Alexandra Tully, Isabelle Vicary, Rosemary Wood, Rachel Battersby, Teela Jullie, Stephanie Savio, Esther Bandala Sanchez, Naiara Bediaga, Chris Hope, Tim Sadlon, Alexandra Roth Schulze, Sabrina Binkowski, Bek Brittain, Minh Bui, Dylan Foskett, Dexing Huang, Stuti Kapadia, Asma Minhaj, Gaetano Naselli, Katrina Ngui, Trung Nguyen, Emily Wood, Cynthia Yau, Leanne Cavenett

Affiliations

¹ Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
² Department of Diabetes and Endocrinology, Women's and Children's Hospital, Adelaide, South Australia, Australia.
³ Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
⁴ School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
⁵ Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
⁶ Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
⁷ The University of Queensland Diamantina Institute, Queensland, Australia.
⁸ Queensland Children's Hospital, South Brisbane, Queensland, Australia.
⁹ Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
¹⁰ Hunter Diabetes Centre, Merewether, New South Wales, Australia.
¹¹ Melbourne eResearch Group, School of Computing and Information Services, University of Melbourne, Melbourne, Victoria, Australia.
¹² Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
¹³ Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Victoria, Australia.
¹⁴ Faculty of Health, School of Medicine, Deakin University, Geelong, Victoria, Australia.
¹⁵ Child Health Research Unit, Barwon Health, Geelong, Victoria, Australia.

PMID: 35107582
DOI: 10.2337/dc21-2335

Abstract

Objective: Pregnancy and type 1 diabetes are each associated with increased anxiety and depression, but the combined impact on well-being is unresolved. We compared the mental health of women with and without type 1 diabetes during pregnancy and postpartum and examined the relationship between mental health and glycemic control.

Research design and methods: Participants were women enrolled from 2016 to 2020 in the Environmental Determinants of Islet Autoimmunity (ENDIA) study, a pregnancy to birth prospective cohort following children with a first-degree relative with type 1 diabetes. Edinburgh Postnatal Depression Scale (EPDS) and Perceived Stress Scale (PSS) were completed during the third trimester (T3) (median [interquartile range] 34 [32, 36] weeks) and postpartum (14 [13, 16] weeks) by 737 women (800 pregnancies) with (n = 518) and without (n = 282) type 1 diabetes.

Results: EPDS and PSS scores did not differ between women with and without type 1 diabetes during T3 and postpartum. EPDS scores were marginally higher in T3: predicted mean (95% CI) 5.7 (5.4, 6.1) than postpartum: 5.3 (5.0, 5.6), independent of type 1 diabetes status (P = 0.01). HbA1c levels in type 1 diabetes were 6.3% [5.8, 6.9%] in T3 and did not correlate with EPDS or PSS scores. Reported use of psychotropic medications was similar in women with (n = 44 of 518 [8%]) and without type 1 diabetes (n = 17 of 282 [6%]), as was their amount of physical activity.

Conclusions: Overall, mental health in late pregnancy and postpartum did not differ between women with and without type 1 diabetes, and mental health scores were not correlated with glycemic control.

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Comment in

Mental Health During Pregnancy and Postpartum in Mothers With Type 1 Diabetes.
Price SAL. Price SAL. Diabetes Care. 2022 May 1;45(5):1027-1028. doi: 10.2337/dci22-0007. Diabetes Care. 2022. PMID: 35561134 No abstract available.

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Mental Health During Late Pregnancy and Postpartum in Mothers With and Without Type 1 Diabetes: The ENDIA Study

Collaborators

Affiliations

Mental Health During Late Pregnancy and Postpartum in Mothers With and Without Type 1 Diabetes: The ENDIA Study

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Collaborators

Affiliations

Abstract

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