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. 2022 Jun;45(3):366-377.
doi: 10.1007/s10865-022-00288-4. Epub 2022 Feb 2.

Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy

Blanca Noriega Esquives  1 , Tae K Lee  2 , Patricia I Moreno  3 , Rina S Fox  4 , Betina Yanez  5 , Gregory E Miller  6 , Ryne Estabrook  7   8 , Mark J Begale  9 , Sarah C Flury  10 , Kent Perry  11 , Shilajit D Kundu  11 , Frank J Penedo  12   13
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Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy

Blanca Noriega Esquives et al. J Behav Med. 2022 Jun.

Abstract

To identify symptom burden profiles among men with advanced prostate cancer undergoing androgen-deprivation therapy and examine their association with baseline sociodemographic and medical characteristics and psychosocial outcomes over time. Latent profile analysis was employed to identify distinct groups based on the Expanded Prostate Index Composite and the McGill Pain Questionnaire at baseline. Psychosocial outcomes were assessed at baseline, 6- and 12-month follow-ups. Three profiles emerged: "high symptom burden," "high sexual bother," and "low symptom burden." Men with "high symptom burden" were younger and exhibited higher baseline levels of depression, stress, cancer-specific distress, and anxiety than men in the other two groups. However, men with "high symptom burden" also demonstrated improvement in these psychosocial outcomes over time. Men with advanced prostate cancer who experience multiple co-occurring symptoms demonstrate worse psychosocial adjustment. Patients with substantial symptom burden, and specifically young men, may benefit from prompt referral to supportive care services.

Keywords: Androgen deprivation therapy; Latent profile analysis; Prostate cancer; Psychosocial well-being; Quality of life; Symptom burden.

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Conflict of interest statement

Conflicts of interest/Competing interests: The authors have no financial or non-financial interests to disclose.

Figures

Figure 1.
Figure 1.
Standardized conditional response means (z-scores) for symptom burden profiles
See this image and copyright information in PMC

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