Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 9;61(20):e202200072.
doi: 10.1002/anie.202200072. Epub 2022 Mar 16.

Widefield SERS for High-Throughput Nanoparticle Screening

Matz Liebel  1 , Irene Calderon  2 , Nicolas Pazos-Perez  2 , Niek F van Hulst  1   3 , Ramon A Alvarez-Puebla  2   3
Affiliations

Widefield SERS for High-Throughput Nanoparticle Screening

Matz Liebel et al. Angew Chem Int Ed Engl. .

Abstract

Surface-enhanced Raman scattering (SERS) imaging is a powerful technology with unprecedent potential for ultrasensitive chemical analysis. Point-by-point scanning and often excessively long spectral acquisition-times hamper the broad exploitation of the full analytical potential of SERS. Here, we introduce large-scale SERS particle screening (LSSPS), a multiplexed widefield screening approach to particle characterization, which is 500-1000 times faster than typical confocal Raman implementations. Beyond its higher throughput, LSSPS simultaneously quantifies both the sample's Raman and Rayleigh scattering to directly quantify the fraction of SERS-active particles which allows for an unprecedented correlation of SERS activity with particle size. .

Keywords: Imaging; Nanoparticles; SERS; Widefield Microscopy.

PubMed Disclaimer

References

    1. None
    1. S. Schlücker, Angew. Chem. Int. Ed. 2014, 53, 4756-4795;
    1. Angew. Chem. 2014, 126, 4852-4894;
    1. J. Langer, D. J. de Aberasturi, J. Aizpurua, R. A. Alvarez-Puebla, B. Auguié, J. J. Baumberg, G. C. Bazan, S. E. J. Bell, A. Boisen, A. G. Brolo, J. Choo, D. Cialla-May, V. Deckert, L. Fabris, K. Faulds, F. Javier García de Abajo, R. Goodacre, D. Graham, A. J. Haes, C. L. Haynes, C. Huck, T. Itoh, M. Käll, J. Kneipp, N. A. Kotov, H. Kuang, E. C. Le Ru, H. K. Lee, J. F. Li, X. Y. Ling, S. A. Maier, T. Mayerhöfer, M. Moskovits, K. Murakoshi, J. M. Nam, S. Nie, Y. Ozaki, I. Pastoriza-Santos, J. Perez-Juste, J. Popp, A. Pucci, S. Reich, B. Ren, G. C. Schatz, T. Shegai, S. Schlücker, L. L. Tay, K. George Thomas, Z. Q. Tian, R. P. van Duyne, T. Vo-Dinh, Y. Wang, K. A. Willets, C. Xu, H. Xu, Y. Xu, Y. S. Yamamoto, B. Zhao, L. M. Liz-Marzán, ACS Nano 2020, 14, 28-117;
    1. M. Fan, G. F. S. Andrade, A. G. Brolo, Anal. Chim. Acta 2020, 1097, 1-29.

Publication types

LinkOut - more resources