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. 2022 Apr;20(4):1015-1018.
doi: 10.1111/jth.15665. Epub 2022 Feb 13.

Investigating potential mechanisms underlying FVIII inhibition in acquired hemophilia A associated with mRNA COVID-19 vaccines

Julia R Hirsiger  1 , Maria Martinez  2 , Dimitrios A Tsakiris  2 , Micol G Cittone  3 , Lukas Graf  4 , Johannes Oldenburg  5 , Behnaz Pezeshkpoor  5 , Mike Recher  6   7 , Jens Mueller  5 , Bernhard Gerber  3   8 , Christoph T Berger  1   7   9
Affiliations

Investigating potential mechanisms underlying FVIII inhibition in acquired hemophilia A associated with mRNA COVID-19 vaccines

Julia R Hirsiger et al. J Thromb Haemost. 2022 Apr.
No abstract available

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Figures

FIGURE 1
FIGURE 1
Factor VIII inhibition by anti‐SARS‐CoV2‐spike‐IgG and the non‐anti‐spike‐IgG fraction. (A) Localization of the potential epitope with sequence similarity between the Factor VIII and the SARS‐CoV2 spike protein. Protein amino acid sequence and gene arrangement were retrieved from UniProtKB, accession number P00451. Amino acid annotations were adapted according to Ref. [14]. (B) Serum anti‐Spike‐IgG/M (Roche Elecsys® Anti‐SARS‐CoV‐2 assay; BAU = binding antibody units). (C) Anti‐spike‐IgG antibodies in the serum of the three patients, the anti‐spike‐IgG‐depleted serum, and the anti‐Spike‐IgG enriched plasma in Luminex. ctrl = serum from three healthy subjects from pre‐pandemic timepoints. (D) Western blot confirms the anti‐spike‐IgG's depletion and enrichment in the respective samples. FVIII mixed serum assay (E), anti‐FVIII binding titers (F), and anti‐FVIII inhibitor titers (G) from the same samples
See this image and copyright information in PMC

References

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