Reply to In vivo confusion over in vivo conversion

Affiliations

¹ Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: chun-li.zhang@utsouthwestern.edu.

Comment

Lei-Lei Wang et al. Mol Ther. 2022.

. 2022 Mar 2;30(3):986-987.

doi: 10.1016/j.ymthe.2022.01.027. Epub 2022 Feb 1.

¹ Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: chun-li.zhang@utsouthwestern.edu.

No abstract available

Comment on

Revisiting astrocyte to neuron conversion with lineage tracing in vivo.
Wang LL, Serrano C, Zhong X, Ma S, Zou Y, Zhang CL. Wang LL, et al. Cell. 2021 Oct 14;184(21):5465-5481.e16. doi: 10.1016/j.cell.2021.09.005. Epub 2021 Sep 27. Cell. 2021. PMID: 34582787 Free PMC article.
In vivo confusion over in vivo conversion.
Chen G. Chen G. Mol Ther. 2021 Nov 3;29(11):3097-3098. doi: 10.1016/j.ymthe.2021.10.017. Epub 2021 Oct 25. Mol Ther. 2021. PMID: 34699780 Free PMC article. No abstract available.

1. Wang L.L., Serrano C., Zhong X., Ma S., Zou Y., Zhang C.L. Revisiting astrocyte to neuron conversion with lineage tracing in vivo. Cell. 2021;184:5465–5481.e5416. doi: 10.1016/j.cell.2021.09.005. - DOI - PMC - PubMed
1. Chen G. In vivo confusion over in vivo conversion. Mol. Ther. 2021;29:3097–3098. doi: 10.1016/j.ymthe.2021.10.017. - DOI - PMC - PubMed
1. Chen Y.C., Ma N.X., Pei Z.F., Wu Z., Do-Monte F.H., Keefe S., Yellin E., Chen M.S., Yin J.C., Lee G., et al. A NeuroD1 AAV-based gene therapy for functional brain repair after ischemic injury through in vivo astrocyte-to-neuron conversion. Mol. Ther. 2020;28:217–234. doi: 10.1016/j.ymthe.2019.09.003. - DOI - PMC - PubMed
1. Wu Z., Parry M., Hou X.Y., Liu M.H., Wang H., Cain R., Pei Z.F., Chen Y.C., Guo Z.Y., Abhijeet S., Chen G. Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease. Nat. Commun. 2020;11:1105. doi: 10.1038/s41467-020-14855-3. - DOI - PMC - PubMed
1. Xiong W., Wu D.M., Xue Y., Wang S.K., Chung M.J., Ji X., Rana P., Zhao S.R., Mai S., Cepko C.L. AAV cis-regulatory sequences are correlated with ocular toxicity. Proc. Natl. Acad. Sci. U S A. 2019;116:5785–5794. doi: 10.1073/pnas.1821000116. - DOI - PMC - PubMed