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Clinical Trial
. 1986 Jan;23(1):94-100.
doi: 10.1016/0090-8258(86)90120-4.

Potentiation of radiotherapy by cis-dichlorodiammine platinum (II) in advanced cervical carcinoma

Y C Choo, T K Choy, L C Wong, H K Ma
Clinical Trial

Potentiation of radiotherapy by cis-dichlorodiammine platinum (II) in advanced cervical carcinoma

Y C Choo et al. Gynecol Oncol. 1986 Jan.

Abstract

Forty-five patients with Stages II and III cervical carcinoma were randomized to receive either radiation or cis-dichlorodiammine platinum (II) (cis-DPP) with radiation. Cis-DPP was administered in bolus injections of 25 mg/m2 at weekly intervals until completion of radium application. Complete response was noted in 11/20 (55%) patients in the radiochemotherapy group compared to 5/25 (20%) patients in the radiation group (P less than 0.025). No enhanced toxicities were observed with the addition of cis-DPP to radiation. The combined use of cis-DPP and radiotherapy offers promising potential in improving local-regional control of advanced cervical carcinoma.

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