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Observational Study
. 2022 Apr;33(4):677-686.
doi: 10.1681/ASN.2022010046. Epub 2022 Feb 2.

The Impact of Vaccination on Incidence and Outcomes of SARS-CoV-2 Infection in Patients with Kidney Failure in Scotland

Samira Bell  1   2   3 , Jacqueline Campbell  2 , Emilie Lambourg  1 , Chrissie Watters  2 , Martin O'Neil  2 , Alison Almond  4 , Katharine Buck  5 , Edward J Carr  1   6 , Laura Clark  7 , Zoe Cousland  8 , Mark Findlay  9 , Nicola Joss  10 , Wendy Metcalfe  11 , Michaela Petrie  11 , Elaine Spalding  12 , Jamie P Traynor  9 , Vinod Sanu  3 , Peter Thomson  9 , Shona Methven  7 , Patrick B Mark  9   13
Affiliations
Observational Study

The Impact of Vaccination on Incidence and Outcomes of SARS-CoV-2 Infection in Patients with Kidney Failure in Scotland

Samira Bell et al. J Am Soc Nephrol. 2022 Apr.

Erratum in

Abstract

Background: Patients with kidney failure requiring KRT are at high risk of complications and death following SARS-CoV-2 infection, with variable antibody responses to vaccination reported. We investigated the effects of COVID-19 vaccination on the incidence of infection, hospitalization, and death from COVID-19 infection.

Methods: The study design was an observational data linkage cohort study. Multiple health care datasets were linked to ascertain all SARS-CoV-2 testing, vaccination, hospitalization, and mortality data for all patients treated with KRT in Scotland from the start of the pandemic over a period of 20 months. Descriptive statistics, survival analyses, and vaccine effectiveness were calculated.

Results: As of September 19, 2021, 93% (n=5281) of the established KRT population in Scotland had received two doses of an approved SARS-CoV-2 vaccine. Over the study period, there were 814 cases of SARS-CoV-2 infection (15.1% of the KRT population). Vaccine effectiveness rates against infection and hospitalization were 33% (95% CI, 0 to 52) and 38% (95% CI, 0 to 57), respectively. Within 28 days of a SARS-CoV-2-positive PCR test, 9.2% of fully vaccinated individuals died (7% patients on dialysis and 10% kidney transplant recipients). This compares to <0.1% of the vaccinated general Scottish population admitted to the hospital or dying due to COVID-19 during that period.

Conclusions: These data demonstrate that a primary vaccine course of two doses has limited effect on COVID-19 infection and its complications in patients with KRT. Adjunctive strategies to reduce risk of both COVID-19 infection and its complications in this population are urgently required.

Keywords: COVID-19; clinical epidemiology; dialysis; kidney replacement therapy; transplantation; vaccination.

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Figures

None
Graphical abstract
Figure 1.
Figure 1.
Vaccination time line for patients on KRT in Scotland. (A) Uptake of first and second doses of vaccine in all patients on KRT in Scotland. (B) Uptake of vaccination in dialysis patients. (C) Uptake of vaccination in kidney transplant patients.
Figure 2.
Figure 2.
Rates and survival of patients on KRT in Scotland positive for SARS-CoV-2. (A) Monthly number of patients on chronic KRT positive for SARS-CoV-2 in Scotland split by status at day 28. (B) Rates and hospitalization of patients on KRT by modality in Scotland positive for SARS-CoV-2.
See this image and copyright information in PMC

Comment in

  • Authors' Reply: Clinical Studies of Vaccine Efficacy.
    Bell S, Campbell J, Lambourg E, Mark P. Bell S, et al. J Am Soc Nephrol. 2022 Jul;33(7):1430-1431. doi: 10.1681/ASN.2022030382. Epub 2022 Jun 21. J Am Soc Nephrol. 2022. PMID: 35728881 Free PMC article. No abstract available.
  • Clinical Studies of Vaccine Efficacy.
    Ashby D. Ashby D. J Am Soc Nephrol. 2022 Jul;33(7):1428-1430. doi: 10.1681/ASN.2022030300. Epub 2022 Jun 21. J Am Soc Nephrol. 2022. PMID: 35728886 Free PMC article. No abstract available.

References

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