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Comment
. 2022 Mar;18(3):126.
doi: 10.1038/s41584-022-00754-y.

B cells: deplete, repopulate, vaccinate

Robert Phillips  1
Affiliations
Comment

B cells: deplete, repopulate, vaccinate

Robert Phillips. Nat Rev Rheumatol. 2022 Mar.

Abstract

In addition to the time since rituximab treatment, new results show that B cell reconstitution is important for response to vaccination in patients with autoimmune rheumatic disease.

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References

    1. Bitoun S, et al. Rituximab impairs B-cell response but not T-cell response to COVID-19 vaccine in auto-immune diseases. Arthritis Rheumatol. 2021 doi: 10.1002/art.42058. - DOI - PMC - PubMed
    1. Jinich S, et al. B-cell reconstitution is strongly associated with COVID-19 vaccine responsiveness in rheumatic disease patients treated with rituximab. Arthritis Rheumatol. 2021 doi: 10.1002/art.42034. - DOI - PubMed
    1. Stefanski AL, et al. B cell numbers predict humoral and cellular response upon SARS-CoV-2 vaccination among patients treated with rituximab. Arthritis Rheumatol. 2021 doi: 10.1002/art.42060. - DOI - PMC - PubMed