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Case Reports
. 2022 Feb;63(2):139-142.

Calcifying aponeurotic fibroma on the paw in a dog

Yeseul Yang  1 , Du-Min Go  1 , Jae-Ha Jung  1 , Dansong Seo  1 , Sung-Hyun Hwang  1 , Dae-Yong Kim  1 , Yongbaek Kim  1
Affiliations
Case Reports

Calcifying aponeurotic fibroma on the paw in a dog

Yeseul Yang et al. Can Vet J. 2022 Feb.

Abstract
in English, French

A 12-year-old, spayed female, Maltese dog with a round and firm mass on the dorsal part of the left rear paw and a cervical mass was brought to the clinic. The paw mass was contiguous to the adjacent tendon; it was composed of neoplastic mesenchymal cells and had scattered foci of calcification with chondroid differentiation microscopically. The neoplastic cells were positive for vimentin and S100, but negative for desmin and smooth muscle actin. Microscopic features and immunohistochemistry results were consistent with calcifying aponeurotic fibroma (CAF). The cervical mass was composed of polygonal cells forming acini with marked anisocytosis and anisokaryosis and diagnosed as thyroid follicular carcinoma. No recurrence or metastasis occurred during follow-up. To the best of our knowledge, this is the first case of canine CAF with features identical to its human counterparts. Key clinical message: This report describes the rare case of calcifying aponeurotic fibroma on the paw in a dog. This is apparently the first case in the veterinary literature with identical clinical and pathological features to the human counterpart.

Fibrome aponévrotique calcifiant sur la patte chez un chien. Une chienne maltaise stérilisée âgée de 12 ans avec une masse ronde et ferme sur la partie dorsale de la patte arrière gauche et une masse cervicale a été amenée à la clinique. La masse de la patte était contiguë au tendon adjacent; il était composé de cellules mésenchymateuses néoplasiques et présentait des foyers de calcification dispersés avec une différenciation chondroïde au microscope. Les cellules néoplasiques étaient positives pour la vimentine et le S100, mais négatives pour la desmine et l’actine des muscles lisses. Les caractéristiques microscopiques et les résultats d’immunohistochimie étaient compatibles avec un fibrome aponévrotique calcifiant (CAF). La masse cervicale était composée de cellules polygonales formant des acini avec une anisocytose et une anisocaryose marquées et diagnostiquée comme un carcinome folliculaire de la thyroïde. Aucune récidive ou métastase n’est survenue au cours du suivi. À notre connaissance, il s’agit du premier cas de CAF canin avec des caractéristiques identiques à ses homologues humains.Message clinique clé :Ce rapport décrit le cas rare de fibrome aponévrotique calcifiant sur la patte chez un chien. C’est apparemment le premier cas dans la littérature vétérinaire avec des caractéristiques cliniques et pathologiques identiques à son homologue humain.(Traduit par Dr Serge Messier).

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Figures

Figure 1
Figure 1
Histology of a paw mass in a dog. A — Note the scattered calcification foci and partial invasion. H&E. 10× Bar = 50 μm. B — Neoplastic cells are well-differentiated spindle cells. H&E. 40× Bar = 10 μm. C — Chondroid differentiation with lacunae and eosinophilic matrix. H&E. 40× Bar = 10 μm. D — Occasional multinucleated giant cells (arrow). H&E. 40× Bar = 10 μm.
Figure 2
Figure 2
Immunohistochemistry (IHC) for vimentin, S100, smooth muscle actin, and desmin in the paw mass of a Maltese dog. 40× Bar = 10 μm (applies to A–D). A–B — Neoplastic cells are positive for vimentin (A) and S100 (B). C — Immunoreactivity to the smooth muscle actin is negative in neoplastic cells, whereas perivascular smooth muscle cells are positive. D — Neoplastic cells do not react with desmin.
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References

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