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. 2021 Dec 18;9(2):ofab638.
doi: 10.1093/ofid/ofab638. eCollection 2022 Feb.

Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals

Silvio Ragozzino  1 , Daniel Goldenberger  2 , Patrick R Wright  3 , Stefan Zimmerli  4 , Konrad Mühlethaler  5 , Dionysios Neofytos  6 , Arnaud Riat  7 , Katia Boggian  8 , Oliver Nolte  9 , Anna Conen  10 , Hans Fankhauser  11 , Peter W Schreiber  12 , Reinhard Zbinden  13 , Frederic Lamoth  14 , Nina Khanna  1
Affiliations

Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals

Silvio Ragozzino et al. Open Forum Infect Dis. .

Abstract

Among 400 Aspergillus species from respiratory samples in Switzerland, Aspergillus fumigatus was the most frequent species. Non-fumigatus Aspergillus spp were more prevalent among solid organ transplant recipients and after azole exposure. Azole resistance was detected in 4 A fumigatus isolates, 3 of them with the "environmental" mutation TR34/L98H in the cyp51A gene.

Keywords: Aspergillus fumigatus; TR34/L98H mutation; azole resistance; cyp51A gene; non-fumigatus Aspergillus spp.

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References

    1. Zanganeh E, Zarrinfar H, Rezaeetalab F, et al. . Predominance of non-fumigatus Aspergillus species among patients suspected to pulmonary aspergillosis in a tropical and subtropical region of the Middle East. Microb Pathog 2018; 116:296–300. - PubMed
    1. Chowdhary A, Sharma C, Meis JF.. Azole-resistant aspergillosis: epidemiology, molecular mechanisms, and treatment. J Infect Dis 2017; 216:S436–44. - PubMed
    1. van der Linden JW, Arendrup MC, Warris A, et al. . Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus. Emerg Infect Dis 2015; 21:1041–4. - PMC - PubMed
    1. De Pau, B, Walsh TJ, Donnelly JP, et al. . Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) consensus group. Clin Infect Dis 2008; 46:1813–21. - PMC - PubMed
    1. Verweij PE, Rijnders BJA, Brüggemann RJM, et al. . Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion. Intensive Care Med 2020; 46:1524–35. - PMC - PubMed