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Review
. 2022 Jul;24(7):1274-1289.
doi: 10.1007/s12094-022-02783-1. Epub 2022 Feb 2.

The role of EphA7 in different tumors

Xiangyi Chen #  1   2   3 , Dechen Yu #  1   2   3 , Haiyu Zhou  4   5   6 , Xiaobo Zhang  1   2   3 , Yicun Hu  1   2   3 , Ruihao Zhang  1   2   3 , Xidan Gao  1   2   3 , Maoqiang Lin  1   2   3 , Taowen Guo  1   2   3 , Kun Zhang  1   2   3
Affiliations
Review

The role of EphA7 in different tumors

Xiangyi Chen et al. Clin Transl Oncol. 2022 Jul.

Abstract

Ephrin receptor A7 (EphA7) is a member of the Eph receptor family. It is widely involved in signal transduction between cells, regulates cell proliferation and differentiation, and participates in developing neural tubes and brain. In addition, EphA7 also has a dual role of tumor promoter and tumor suppressor. It can participate in cell proliferation, migration and apoptosis through various mechanisms, and affect tumor differentiation, staging and prognosis. EphA7 may be a potential diagnostic marker and tumor treatment target. This article reviews the effects of EphA7 on a variety of tumor biological processes and pathological characteristics, as well as specific effects and regulatory mechanisms.

Keywords: Diagnostic markers; Ephrin receptor A7 (EphA7); Mechanism; Prognosis; Therapeutic target; Tumor.

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