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Observational Study
. 2022 Feb 4;60(5):793-799.
doi: 10.1515/cclm-2022-0027. Print 2022 Apr 26.

Perinatal asphyxia partly affects presepsin urine levels in non-infected term infants

Valentina Botondi  1 , Alice Pirra  2 , Mariachiara Strozzi  3 , Marika Perrotta  1 , Danilo A W Gavilanes  4 , Laura Di Ricco  1 , Cynzia Spagnuolo  1 , Antonio Maconi  3 , Andrea Rocchetti  3 , Laura Mazzucco  3 , Valeria Balbo  3 , Federico Schena  3 , Giuseppina Stellitano  3 , Arianna Oddi  3 , Andrea Dotta  5 , Iliana Bersani  5 , Andrea Sannia  2 , Chiara Peila  6 , Enrico Bertino  6 , Ines Bianco  7 , Alessandra Gambi  7 , Rocco Mangifesta  8 , Diego Gazzolo  1
Affiliations
Free article
Observational Study

Perinatal asphyxia partly affects presepsin urine levels in non-infected term infants

Valentina Botondi et al. Clin Chem Lab Med. .
Free article

Abstract

Objectives: Standard of care sepsis biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT) can be affected by several perinatal factors, among which perinatal asphyxia (PA) has a significant role. In this light, new early sepsis biomarkers such as presepsin (P-SEP) are needed to enact therapeutic strategies at a stage when clinical and laboratory patterns are still silent or unavailable. We aimed at investigating the potential effects of PA on longitudinal P-SEP urine levels.

Methods: We conducted an observational case-control study in 76 term infants, 38 with PA and 38 controls. Standard clinical, laboratory, radiological monitoring procedures and P-SEP urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth.

Results: Higher (p<0.05) CRP and PCT blood levels at T1-T3 were observed in PA than control infants whilst no differences (p>0.05, for all) at T0 were observed between groups. P-SEP urine levels were higher (p<0.05) in PA at first void and at 24 h while no differences (p>0.05) at 48 and 96 h were observed. No significant correlations were found (p>0.05) between P-SEP and urea (R=0.11) and creatinine (R=0.02) blood levels, respectively.

Conclusions: The present results, showed that PA effects on P-SEP were limited up to the first 24 h following birth in absence of any kidney function bias. Data open the way to further investigations aimed at validating P-SEP assessment in non-invasive biological fluids as a reliable tool for early EOS and LOS detection in high-risk infants.

Keywords: kidney; newborn; perinatal asphyxia (PA); presepsin (P-SEP); sepsis.

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