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Editorial
. 2022 Feb 3;139(5):640-642.
doi: 10.1182/blood.2021014337.

Stressed and disoriented: stromal autophagy regulates HSCs

Stephanie N Hurwitz  1 , Peter Kurre  2
Affiliations
Editorial

Stressed and disoriented: stromal autophagy regulates HSCs

Stephanie N Hurwitz et al. Blood. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
Proposed mechanisms of crosstalk between MSPCs and HSCs downstream of Wnt5a-CDC42–dependent actin organization. MSPC cytoskeletal polarity facilitates cell contact–dependent HSC orientation and bidirectional tunneling nanotube-mediated transfer of ROS and mitochondria. Cytoskeleton-dependent secretory autophagy contributes to the MSPC secretome, in part regulating release of freely secreted HSC-supportive factors, extracellular vesicles, and vesicle-bound mitochondria. Professional illustration by Somersault 18:24.
See this image and copyright information in PMC

Comment on

References

    1. Landspersky T, Saçma M, Rivière J, et al. . Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress. Blood. 2022;139(5):690-703. - PMC - PubMed
    1. Ho TT, Warr MR, Adelman ER, et al. . Autophagy maintains the metabolism and function of young and old stem cells. Nature. 2017;543(7644):205-210. - PMC - PubMed
    1. Rastaldo R, Vitale E, Giachino C. Dual role of autophagy in regulation of mesenchymal stem cell senescence. Front Cell Dev Biol. 2020;8:276. - PMC - PubMed
    1. Schreck C, Istvánffy R, Ziegenhain C, et al. . Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. J Exp Med. 2017;214(1):165-181. - PMC - PubMed
    1. Florian MC, Geiger H. Concise review: polarity in stem cells, disease, and aging. Stem Cells. 2010;28(9):1623-1629. - PMC - PubMed