Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

doi:10.1007/s12072-021-10285-5

Review

. 2022 Apr;16(2):211-253.

doi: 10.1007/s12072-021-10285-5. Epub 2022 Feb 3.

Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

Manoj Kumar¹, Zaigham Abbas², Milad Azami³, Maria Belopolskaya⁴, A K Dokmeci⁵, Hasmik Ghazinyan⁶, Jidong Jia⁷, Ankur Jindal⁸, Han Chu Lee⁹, Wei Lei¹⁰, Seng Gee Lim¹¹, Chun-Jen Liu¹², Qiang Li¹³, Mamun Al Mahtab¹⁴, David H Muljono¹⁵, Madunil Anuk Niriella¹⁶, Masao Omata^{17

18}, Diana A Payawal¹⁹, Shiv K Sarin²⁰, Olivier Ségéral²¹, Tawesak Tanwandee²², Nirupma Trehanpati²³, Kumar Visvanathan²⁴, Jin Mo Yang²⁵, Man-Fung Yuen²⁶, Yingjie Zheng²⁷, Y H Zhou²⁸

Affiliations

¹ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India. manojkumardm@gmail.com.
² Department of Medicine, Ziauddin University Hospital, Karachi, Pakistan.
³ Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
⁴ Botkin Infectious Diseases Hospital, Saint Petersburg, Russia.
⁵ Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey.
⁶ Department of Hepatology, Nork Clinical Hospital of Infectious Disease, Yerevan, Armenia.
⁷ Liver Research Center, Beijing Friendship Hospital, Capital Medial University, Beijing, China.
⁸ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.
⁹ Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
¹⁰ Hepatopancreatobiliary Center, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
¹¹ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹² Department of Internal Medicine and Hepatitis Research Center, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan.
¹³ Division of Liver Diseases Jinan Infectious Disease Hospital, Shandong University, Jinan, China.
¹⁴ Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
¹⁵ Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
¹⁶ Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Colombo, Sri Lanka.
¹⁷ Department of Gastroenterology, Yamanashi Central Hospital, Yamanashi, Japan.
¹⁸ University of Tokyo, Tokyo, Japan.
¹⁹ Fatima University Medical Center Manila, Manila, Philippines.
²⁰ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India. shivsarin@gmail.com.
²¹ French Agency for Research on AIDS and Viral Hepatitis, University of Health Science, Phnom Penh, Cambodia.
²² Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
²³ Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
²⁴ Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.
²⁵ Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
²⁶ Li Shu Fan Medical Foundation Professor in Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
²⁷ Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
²⁸ Department of Laboratory Medicine, Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

PMID: 35113359
DOI: 10.1007/s12072-021-10285-5

Review

Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

Manoj Kumar et al. Hepatol Int. 2022 Apr.

. 2022 Apr;16(2):211-253.

doi: 10.1007/s12072-021-10285-5. Epub 2022 Feb 3.

Authors

Affiliations

¹ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India. manojkumardm@gmail.com.
² Department of Medicine, Ziauddin University Hospital, Karachi, Pakistan.
³ Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
⁴ Botkin Infectious Diseases Hospital, Saint Petersburg, Russia.
⁵ Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey.
⁶ Department of Hepatology, Nork Clinical Hospital of Infectious Disease, Yerevan, Armenia.
⁷ Liver Research Center, Beijing Friendship Hospital, Capital Medial University, Beijing, China.
⁸ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.
⁹ Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
¹⁰ Hepatopancreatobiliary Center, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
¹¹ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹² Department of Internal Medicine and Hepatitis Research Center, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan.
¹³ Division of Liver Diseases Jinan Infectious Disease Hospital, Shandong University, Jinan, China.
¹⁴ Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
¹⁵ Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
¹⁶ Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Colombo, Sri Lanka.
¹⁷ Department of Gastroenterology, Yamanashi Central Hospital, Yamanashi, Japan.
¹⁸ University of Tokyo, Tokyo, Japan.
¹⁹ Fatima University Medical Center Manila, Manila, Philippines.
²⁰ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India. shivsarin@gmail.com.
²¹ French Agency for Research on AIDS and Viral Hepatitis, University of Health Science, Phnom Penh, Cambodia.
²² Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
²³ Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
²⁴ Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.
²⁵ Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
²⁶ Li Shu Fan Medical Foundation Professor in Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
²⁷ Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
²⁸ Department of Laboratory Medicine, Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

PMID: 35113359
DOI: 10.1007/s12072-021-10285-5

Abstract

Hepatitis B virus (HBV) infection still remains a major public health issue in the Asia-Pacific region. Most of the burden of HBV-related disease results from infections acquired in infancy through perinatal or early childhood exposure to HBV in Asia-Pacific. Hepatitis B during pregnancy presents unique management issues for both the mother and fetus. These APASL guidelines provide a comprehensive review and recommendations based on available evidence in the literature, for the management of females with HBV infection through every stage of pregnancy and postpartum. These also address the concerns, management challenges, and required follow-up of children born to hepatitis B-positive mothers.

Keywords: Acute Hepatitis B; Chronic Hepatitis B; Hepatitis B; Pregnancy.

PubMed Disclaimer

Comment in

HBV in pregnancy: time to consider tenofovir alafenamide (TAF).
Parveen S, Tiwari A, Singh J, Shah A. Parveen S, et al. Hepatol Int. 2022 Aug;16(4):974-975. doi: 10.1007/s12072-022-10382-z. Epub 2022 Jul 6. Hepatol Int. 2022. PMID: 35793040 No abstract available.
Tenofovir Alafenamide use in pregnant women with chronic hepatitis B virus infection: more data needed.
Kumar M. Kumar M. Hepatol Int. 2022 Aug;16(4):973. doi: 10.1007/s12072-022-10376-x. Epub 2022 Jul 6. Hepatol Int. 2022. PMID: 35794305 No abstract available.

Cited by

A high functional cure rate was induced by pegylated interferon alpha-2b treatment in postpartum hepatitis B e antigen-negative women with chronic hepatitis B virus infection: an exploratory study.
Zhong W, Yan L, Zhu Y, Shi L, He Y, Chen T, Zheng J. Zhong W, et al. Front Cell Infect Microbiol. 2024 Aug 8;14:1426960. doi: 10.3389/fcimb.2024.1426960. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 39176265 Free PMC article.
Current treatment of chronic hepatitis B: Clinical aspects and future directions.
Zhu M, Wang H, Lou T, Xiong P, Zhang J, Li L, Sun Y, Wu Y. Zhu M, et al. Front Microbiol. 2022 Sep 8;13:975584. doi: 10.3389/fmicb.2022.975584. eCollection 2022. Front Microbiol. 2022. PMID: 36160238 Free PMC article. Review.
Diagnostic Approach to Elevated Liver Function Tests during Pregnancy: A Pragmatic Narrative Review.
Dajti E, Bruni A, Barbara G, Azzaroli F. Dajti E, et al. J Pers Med. 2023 Sep 16;13(9):1388. doi: 10.3390/jpm13091388. J Pers Med. 2023. PMID: 37763154 Free PMC article.
Effects of hepatitis B virus infection and strategies for preventing mother-to-child transmission on maternal and fetal T-cell immunity.
Lu H, Cao W, Zhang L, Yang L, Bi X, Lin Y, Deng W, Jiang T, Sun F, Zeng Z, Lu Y, Zhang L, Liu R, Gao Y, Wu S, Hao H, Chen X, Hu L, Xu M, Xiong Q, Dong J, Song R, Li M, Xie Y. Lu H, et al. Front Immunol. 2023 Feb 16;14:1122048. doi: 10.3389/fimmu.2023.1122048. eCollection 2023. Front Immunol. 2023. PMID: 36875136 Free PMC article. Review.
Guidelines for the Prevention and Treatment of Chronic Hepatitis B (version 2022).
You H, Wang F, Li T, Xu X, Sun Y, Nan Y, Wang G, Hou J, Duan Z, Wei L, Jia J, Zhuang H; Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Infectious Diseases, Chinese Medical Association. You H, et al. J Clin Transl Hepatol. 2023 Nov 28;11(6):1425-1442. doi: 10.14218/JCTH.2023.00320. Epub 2023 Aug 15. J Clin Transl Hepatol. 2023. PMID: 37719965 Free PMC article.

See all "Cited by" articles

References

1. Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, et al. Grading quality of evidence and strength of recommendations. BMJ. 2004;328:1490 - DOI
1. Sarin SK, Kumar M, Eslam M, George J, Al Mahtab M, Akbar SMF, et al. Liver diseases in the Asia–Pacific region: a Lancet Gastroenterology and Hepatology Commission. Lancet Gastroenterol Hepatol. 2020;5(2):167–228 - DOI
1. World Health Organization. Operationalizing elimination of mother-to-child transmission of Hepatitis B virus in the Western Pacific Region. World Health Organization Regional Office for the Western Pacific, Manila, Licence: CC BY-NC-SA 3.0 IGO. 2021
1. World Health Organization. Global health sector strategy on viral hepatitis 2016–2021. World Health Organization, Geneva. 2016. ( http://www.who.int/hepatitis/strategy2016-2021/ghss-hep/en/ )
1. https://www.globalhep.org/country-data-dashboards

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information

[1] Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, et al. Grading quality of evidence and strength of recommendations. BMJ. 2004;328:1490 - DOI

[2] Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, et al. Grading quality of evidence and strength of recommendations. BMJ. 2004;328:1490 - DOI

[3] Sarin SK, Kumar M, Eslam M, George J, Al Mahtab M, Akbar SMF, et al. Liver diseases in the Asia–Pacific region: a Lancet Gastroenterology and Hepatology Commission. Lancet Gastroenterol Hepatol. 2020;5(2):167–228 - DOI

[4] Sarin SK, Kumar M, Eslam M, George J, Al Mahtab M, Akbar SMF, et al. Liver diseases in the Asia–Pacific region: a Lancet Gastroenterology and Hepatology Commission. Lancet Gastroenterol Hepatol. 2020;5(2):167–228 - DOI

[5] World Health Organization. Operationalizing elimination of mother-to-child transmission of Hepatitis B virus in the Western Pacific Region. World Health Organization Regional Office for the Western Pacific, Manila, Licence: CC BY-NC-SA 3.0 IGO. 2021

[6] World Health Organization. Operationalizing elimination of mother-to-child transmission of Hepatitis B virus in the Western Pacific Region. World Health Organization Regional Office for the Western Pacific, Manila, Licence: CC BY-NC-SA 3.0 IGO. 2021

[7] World Health Organization. Global health sector strategy on viral hepatitis 2016–2021. World Health Organization, Geneva. 2016. ( http://www.who.int/hepatitis/strategy2016-2021/ghss-hep/en/ )

[8] World Health Organization. Global health sector strategy on viral hepatitis 2016–2021. World Health Organization, Geneva. 2016. ( http://www.who.int/hepatitis/strategy2016-2021/ghss-hep/en/ )

[9] https://www.globalhep.org/country-data-dashboards

[10] https://www.globalhep.org/country-data-dashboards

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

Affiliations

Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

Authors

Affiliations

Abstract

Comment in

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Abstract

Comment in

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Medical