Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

Manoj Kumar¹, Zaigham Abbas², Milad Azami³, Maria Belopolskaya⁴, A K Dokmeci⁵, Hasmik Ghazinyan⁶, Jidong Jia⁷, Ankur Jindal⁸, Han Chu Lee⁹, Wei Lei¹⁰, Seng Gee Lim¹¹, Chun-Jen Liu¹², Qiang Li¹³, Mamun Al Mahtab¹⁴, David H Muljono¹⁵, Madunil Anuk Niriella¹⁶, Masao Omata^{17

18}, Diana A Payawal¹⁹, Shiv K Sarin²⁰, Olivier Ségéral²¹, Tawesak Tanwandee²², Nirupma Trehanpati²³, Kumar Visvanathan²⁴, Jin Mo Yang²⁵, Man-Fung Yuen²⁶, Yingjie Zheng²⁷, Y H Zhou²⁸

Affiliations

¹ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India. manojkumardm@gmail.com.
² Department of Medicine, Ziauddin University Hospital, Karachi, Pakistan.
³ Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
⁴ Botkin Infectious Diseases Hospital, Saint Petersburg, Russia.
⁵ Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey.
⁶ Department of Hepatology, Nork Clinical Hospital of Infectious Disease, Yerevan, Armenia.
⁷ Liver Research Center, Beijing Friendship Hospital, Capital Medial University, Beijing, China.
⁸ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.
⁹ Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
¹⁰ Hepatopancreatobiliary Center, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
¹¹ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹² Department of Internal Medicine and Hepatitis Research Center, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan.
¹³ Division of Liver Diseases Jinan Infectious Disease Hospital, Shandong University, Jinan, China.
¹⁴ Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
¹⁵ Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
¹⁶ Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Colombo, Sri Lanka.
¹⁷ Department of Gastroenterology, Yamanashi Central Hospital, Yamanashi, Japan.
¹⁸ University of Tokyo, Tokyo, Japan.
¹⁹ Fatima University Medical Center Manila, Manila, Philippines.
²⁰ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India. shivsarin@gmail.com.
²¹ French Agency for Research on AIDS and Viral Hepatitis, University of Health Science, Phnom Penh, Cambodia.
²² Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
²³ Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
²⁴ Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.
²⁵ Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
²⁶ Li Shu Fan Medical Foundation Professor in Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
²⁷ Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
²⁸ Department of Laboratory Medicine, Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

PMID: 35113359
DOI: 10.1007/s12072-021-10285-5

Review

Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

Manoj Kumar et al. Hepatol Int. 2022 Apr.

. 2022 Apr;16(2):211-253.

doi: 10.1007/s12072-021-10285-5. Epub 2022 Feb 3.

Authors

Affiliations

¹ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India. manojkumardm@gmail.com.
² Department of Medicine, Ziauddin University Hospital, Karachi, Pakistan.
³ Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
⁴ Botkin Infectious Diseases Hospital, Saint Petersburg, Russia.
⁵ Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey.
⁶ Department of Hepatology, Nork Clinical Hospital of Infectious Disease, Yerevan, Armenia.
⁷ Liver Research Center, Beijing Friendship Hospital, Capital Medial University, Beijing, China.
⁸ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.
⁹ Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
¹⁰ Hepatopancreatobiliary Center, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
¹¹ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹² Department of Internal Medicine and Hepatitis Research Center, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan.
¹³ Division of Liver Diseases Jinan Infectious Disease Hospital, Shandong University, Jinan, China.
¹⁴ Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
¹⁵ Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
¹⁶ Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Colombo, Sri Lanka.
¹⁷ Department of Gastroenterology, Yamanashi Central Hospital, Yamanashi, Japan.
¹⁸ University of Tokyo, Tokyo, Japan.
¹⁹ Fatima University Medical Center Manila, Manila, Philippines.
²⁰ Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India. shivsarin@gmail.com.
²¹ French Agency for Research on AIDS and Viral Hepatitis, University of Health Science, Phnom Penh, Cambodia.
²² Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
²³ Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
²⁴ Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.
²⁵ Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
²⁶ Li Shu Fan Medical Foundation Professor in Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
²⁷ Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
²⁸ Department of Laboratory Medicine, Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

PMID: 35113359
DOI: 10.1007/s12072-021-10285-5

Abstract

Hepatitis B virus (HBV) infection still remains a major public health issue in the Asia-Pacific region. Most of the burden of HBV-related disease results from infections acquired in infancy through perinatal or early childhood exposure to HBV in Asia-Pacific. Hepatitis B during pregnancy presents unique management issues for both the mother and fetus. These APASL guidelines provide a comprehensive review and recommendations based on available evidence in the literature, for the management of females with HBV infection through every stage of pregnancy and postpartum. These also address the concerns, management challenges, and required follow-up of children born to hepatitis B-positive mothers.

Keywords: Acute Hepatitis B; Chronic Hepatitis B; Hepatitis B; Pregnancy.

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Comment in

HBV in pregnancy: time to consider tenofovir alafenamide (TAF).
Parveen S, Tiwari A, Singh J, Shah A. Parveen S, et al. Hepatol Int. 2022 Aug;16(4):974-975. doi: 10.1007/s12072-022-10382-z. Epub 2022 Jul 6. Hepatol Int. 2022. PMID: 35793040 No abstract available.
Tenofovir Alafenamide use in pregnant women with chronic hepatitis B virus infection: more data needed.
Kumar M. Kumar M. Hepatol Int. 2022 Aug;16(4):973. doi: 10.1007/s12072-022-10376-x. Epub 2022 Jul 6. Hepatol Int. 2022. PMID: 35794305 No abstract available.

References

1. Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, et al. Grading quality of evidence and strength of recommendations. BMJ. 2004;328:1490 - DOI
1. Sarin SK, Kumar M, Eslam M, George J, Al Mahtab M, Akbar SMF, et al. Liver diseases in the Asia–Pacific region: a Lancet Gastroenterology and Hepatology Commission. Lancet Gastroenterol Hepatol. 2020;5(2):167–228 - DOI
1. World Health Organization. Operationalizing elimination of mother-to-child transmission of Hepatitis B virus in the Western Pacific Region. World Health Organization Regional Office for the Western Pacific, Manila, Licence: CC BY-NC-SA 3.0 IGO. 2021
1. World Health Organization. Global health sector strategy on viral hepatitis 2016–2021. World Health Organization, Geneva. 2016. ( http://www.who.int/hepatitis/strategy2016-2021/ghss-hep/en/ )
1. https://www.globalhep.org/country-data-dashboards

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Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

Affiliations

Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

Authors

Affiliations

Abstract

Comment in

References

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Full Text Sources

Medical