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Review
. 2022;38(4):e2021045.
doi: 10.36141/svdld.v38i4.11808. Epub 2022 Jan 13.

MPO-ANCA positive interstitial pneumonia: Current knowledge and future perspectives

Masashi Bando  1 , Sakae Homma  2 , Masayoshi Harigai  3
Affiliations
Review

MPO-ANCA positive interstitial pneumonia: Current knowledge and future perspectives

Masashi Bando et al. Sarcoidosis Vasc Diffuse Lung Dis. 2022.

Abstract

Although interstitial pneumonia is an important respiratory manifestation in microscopic polyangiitis (MPA), no studies have examined the detailed pathogenesis of interstitial pneumonia during the clinical course of MPA. In addition, it is considered that MPA develops at a certain incidence rate from myeloperoxidase (MPO)- antineutrophil cytoplasmic antibody (ANCA) positive interstitial pneumonia. However, there is a lack of consensus among pulmonologist and rheumatologist regarding whether MPO-ANCA positive interstitial pneumonia, which does not accompany other organ damage related to ANCA-associated vasculitis (AAV) other than interstitial pneumonia, should be included in AAV. In this review article, the clinical questions regarding MPO-ANCA positive interstitial pneumonia have been set, and evidence to date and problems to be solved in future are outlined.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article.

Figures

Figure 1.
Figure 1.
MPO-ANCA positive interstitial pneumonia from the perspective of pulmonologists and non-pulmonologists
Figure 2.
Figure 2.
Disease concept and related CQs for
See this image and copyright information in PMC

References

    1. Alba MA, Flores-Suárez LF, Henderson AG, Xiao H, Hu P, Nachman PH, et al. Interstitial lung disease in ANCA vasculitis. Autoimmunity Reviews. 2017;16:722–729. - PMC - PubMed
    1. Katsumata Y, Kawaguchi Y, Yamanaka H. Interstitial lung disease with ANCA-associated vasculitis. Clin Med Insights Circ Respir Pulm Med. 2015;9:51–56. - PMC - PubMed
    1. Schirmer JH, Wright MN, Vonthein R, Herrmann K, Nölle B, Both M, et al. Clinical presentation and long-term outcome of 144 patients with microscopic polyangiitis in a monocentric German cohort. Rheumatology. 2016;55:71–79. - PubMed
    1. Sacoto G, Boukhlal S, Specks U, Flores-Suárez LF, Cornec D. Lung involvement in ANCA-associated vasculitis. Presse Med. 2020;49:104039. - PubMed
    1. Karras A. Microscopic polyangiitis: new insights into pathogenesis, clinical features and therapy. Semi Respir Crit Care Med. 2018;39:459–464. - PubMed

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