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Editorial
. 2022 Jan 18:12:826363.
doi: 10.3389/fimmu.2021.826363. eCollection 2021.

Editorial: Type I and Type III Interferon Immune Responses in Asthma

Susetta Finotto  1 , Tuomas Jartti  2   3   4 , Sebastian L Johnston  5
Affiliations
Editorial

Editorial: Type I and Type III Interferon Immune Responses in Asthma

Susetta Finotto et al. Front Immunol. .
No abstract available

Keywords: air pollution; allergic asthma; children; interferons; rhinovirus.

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Conflict of interest statement

SLJ is an author on patents on the use of inhaled interferons for the treatment of exacerbations of airway diseases. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The integrity of the epithelial respiratory barrier is important to protect from environmental triggers. (A) Innocuous antigens, environmental particles and viruses damage the integrity of the mucosal epithelium barrier. The respiratory mucosal epithelium barrier must facilitate selective transport as well as restrict free exchange across the para-cellular spaces. These functions are facilitated by the tight junctions (TJs), which are molecular structures between cells allowing closest cell to cell contact. They regulate the permeability of ions, (macro) molecules and cells via the paracellular pathway. Virus-infected epithelial cells are an important immediate source of IFNs, as well as later production by dendritic cells (DCs) and alveolar macrophages (AMs). (B) In contrast, lack of exogenous triggers maintains an intact respiratory epithelial barrier. This figure was created using Servier Medical Art templates, which are licensed under a Creative Commons Attribution 3.0 Unported License; https://smart.servier.com.
See this image and copyright information in PMC

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  • Editorial on the Research Topic Type I and Type III Interferon Immune Responses in Asthma

References

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