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Case Reports
. 2019 Jun;8(3):996-1000.
doi: 10.21037/tcr.2019.05.13.

Successful treatment of giant mesenteric fibromatosis with surgery and tamoxifen: case report

Zhixiang Jin  1 , Qi Zhang  2 , Dong Tang  2 , Liuhua Wang  2 , Wei Wang  2 , Minghao Xu  1 , Zhi Li  1 , Daorong Wang  2
Affiliations
Case Reports

Successful treatment of giant mesenteric fibromatosis with surgery and tamoxifen: case report

Zhixiang Jin et al. Transl Cancer Res. 2019 Jun.

Abstract

A 65-year-old man underwent excision of a giant mesenteric fibromatosis (MF) via combined splenectomy and partial transverse colectomy. Pathological examination confirmed the presence of MF, whereas genetic testing indicated that the tumor was sensitive to tamoxifen. Over a 1-year follow-up, no symptoms of abdominal discomfort or recurrence was noted.

Keywords: Aggressive fibromatosis (AF); desmoid-type fibromatosis; mesenteric fibromatosis (MF); tamoxifen.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tcr.2019.05.13). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Computed tomography (CT) showed a 16 cm × 12 cm space-occupying lesion in the left upper abdomen.
Figure 2
Figure 2
The tumor was completely resected via splenectomy and segmental transverse colectomy.
Figure 3
Figure 3
The results of HE staining and immunohistochemistry. (A,B) HE staining showed the arrangement of abundant cells in a fascicle (A) or whirlpool (B) manner. (C,D,E) Immunohistochemistry indicated vimentin(+) (C), SMA(+) (D), and β-catenin(+) (E). Magnification, ×100.
See this image and copyright information in PMC

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