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Review
. 2019 Oct;8(Suppl 5):S510-S517.
doi: 10.21037/tcr.2019.07.38.

Angiosarcoma of the breast, the unknown-a review of the current literature

Emanuela Esposito  1   2 , Franca Avino  1 , Raimondo di Giacomo  1 , Ivana Donzelli  1 , Ugo Marone  1 , Maria Teresa Melucci  1 , Chiara Rinaldo  3 , Fulvio Ruffolo  1 , Ruggero Saponara  1 , Claudio Siani  1 , Raffaele Tortoriello  1 , Gerardo Botti  4 , Massimo Rinaldo  1 , Alfredo Fucito  1
Affiliations
Review

Angiosarcoma of the breast, the unknown-a review of the current literature

Emanuela Esposito et al. Transl Cancer Res. 2019 Oct.

Abstract

Angiosarcoma of the breast is one of the rarest malignancies. Breast angiosarcoma can be classified into primary when arising de novo and secondary to chronic lymphoedema or breast irradiation. Molecular pathways involved in angiosarcoma development have not been described clearly, yet some gene point mutations and protein altered expression levels have been detected. So far, their management is based above all on surgery. Hence, further studies starting from the few known key points may help to develop more effective strategies based both on target therapies, together with surgery.

Keywords: Angiosarcoma; breast; mesenchymal tumours.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tcr.2019.07.38). The focused issue “Rare Tumors of the Breast” was commissioned by the editorial office without any funding or sponsorship. EE served as the unpaid Guest Editor for the focused issue and serves as the unpaid editorial board member of Translational Cancer Research from May 2018 to Apr 2020. The other authors have no other conflicts of interest to declare.

Figures

Figure 1
Figure 1
Secondary radio-induced angiosarcoma of the breast.
See this image and copyright information in PMC

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