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Editorial
. 2019 Dec;8(Suppl 6):S606-S611.
doi: 10.21037/tcr.2019.09.08.

New approaches to model glioblastoma in vitro using brain organoids: implications for precision oncology

Guillermo A Gomez #  1 , Mariana Oksdath #  1 , Michael P Brown  1   2   3 , Lisa M Ebert  1
Affiliations
Editorial

New approaches to model glioblastoma in vitro using brain organoids: implications for precision oncology

Guillermo A Gomez et al. Transl Cancer Res. 2019 Dec.
No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tcr.2019.09.08). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
A new cerebral organoid model for the study of brain cancer. Brain organoid cultures, grown from stem cells, can mimic a developing human brain. The most critical features reproduced in brain organoids involve the forebrain formation and regionalization, with a key cellular composition that results in the typical layering formation of the cerebral cortex. To address the interaction between tumor cells and the healthy brain tissue, patient-derived glioblastoma cells are isolated from pathological tissue obtained after surgical tumor resection and cultured as glioma stem cells (GSCs). GSCs are then co-cultured with a developing brain organoid, resulting in the main clinical features of glioblastoma, such as invasiveness and extensive necrosis, being maintained in this system. MZ, marginal zone; CP, cortical plate; IZ, intermediate zone; SVZ, sub-ventricular zone; VZ, ventricular zone.
See this image and copyright information in PMC

Comment on

  • Modeling Patient-Derived Glioblastoma with Cerebral Organoids.
    Linkous A, Balamatsias D, Snuderl M, Edwards L, Miyaguchi K, Milner T, Reich B, Cohen-Gould L, Storaska A, Nakayama Y, Schenkein E, Singhania R, Cirigliano S, Magdeldin T, Lin Y, Nanjangud G, Chadalavada K, Pisapia D, Liston C, Fine HA. Linkous A, et al. Cell Rep. 2019 Mar 19;26(12):3203-3211.e5. doi: 10.1016/j.celrep.2019.02.063. Cell Rep. 2019. PMID: 30893594 Free PMC article.

References

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