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Editorial
. 2020 Mar;9(3):1322-1325.
doi: 10.21037/tcr.2020.01.31.

Pediatric cerebellar tumors: transcriptionally distinct but developmentally heterogeneous

Debanjan Bhattacharya  1 , Daniel Pomeranz Krummel  1 , Soma Sengupta  1   2
Affiliations
Editorial

Pediatric cerebellar tumors: transcriptionally distinct but developmentally heterogeneous

Debanjan Bhattacharya et al. Transl Cancer Res. 2020 Mar.
No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tcr.2020.01.31). DPK declares being on a patent application (19109 PCT) filed from Emory University which is currently in pending status. SS reports that she has provided consulting support to Novocure, as an advisory committee member once and has received an income from Novocure for consultation provided. In addition to this Dr. Sengupta has patent 19109 PCT filed from Emory University in pending status. The authors have no other conflicts of interest to declare.

Figures

Figure 1
Figure 1
Cerebellar neurogenesis and pediatric cerebellar tumors. (A) Cerebellar neurogenesis from primary germinal zones (cerebellar ventricular and rhombic lip) (top) leading to the formation of three main cerebellar layers (molecular, Purkinje, and granular) and some of the key neural cells as shown in hematoxylin and eosin (H&E) stained image of mouse cerebellum (bottom); (B) common pediatric cerebellar tumors and their relative sites of origin in the CNS. Shown are: medulloblastoma (MB) subgroups (sonic hedgehog-activated (SHH); wnt-activated (WNT); Group 3; Group 4; posterior fossa ependymomas (PFA and PFB); cerebellar pilocytic astrocytomas (C-PAs).
See this image and copyright information in PMC

Comment on

  • Childhood cerebellar tumours mirror conserved fetal transcriptional programs.
    Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD. Vladoiu MC, et al. Nature. 2019 Aug;572(7767):67-73. doi: 10.1038/s41586-019-1158-7. Epub 2019 May 1. Nature. 2019. PMID: 31043743 Free PMC article.

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