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Case Reports
. 2020 Mar;9(3):2037-2039.
doi: 10.21037/tcr.2019.12.24.

Epithelioid trophoblastic tumor found on hysteroscopy

Di Zhang  1 , Wenchao Sun  2 , Dingheng Li  2 , Zhifen Zhang  2
Affiliations
Case Reports

Epithelioid trophoblastic tumor found on hysteroscopy

Di Zhang et al. Transl Cancer Res. 2020 Mar.

Abstract

A 36-year-old woman presented with a history of prolonged menstrual period and increased menstrual volume of 4 months. Ultrasonography showed inhomogeneous echo measuring 2.5×1.9×2.2 cm3 in uterine cavity, and it can be seen that the blood flow signal enters the uterine posterior wall. Trophoblastic disease was not ruled out. But the serum β-human chorionic gonadotropin (hCG) was <0.3 mIU/mL. In order to confirm the diagnosis, the patient was planned to undergo hysteroscopy. Hysteroscopy is an ideal solution for early diagnosis. However, the drawback of hysteroscopy is that only local lesions can be removed. If the infiltration degree is deep, a second hysterectomy is required. Our authors present the first case of epithelioid trophoblastic tumor (ETT) under hysteroscopy. After neoplasm partial resection, histopathological examination revealed ETT. The patient underwent hysterectomy to prevent recurrence.

Keywords: Epithelioid trophoblastic tumor (ETT); case report; hysteroscopy.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tcr.2019.12.24). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
A neoplasm sticking out of the cavity that measuring 2×2×1.5 cm3 in size in the left side of uterine cavity.
Figure 2
Figure 2
Surface vessels (arrow heads) of the neoplasm were rich and tortuous.
Figure 3
Figure 3
After neoplasm partial resection, hysteroscopy revealed dense and visible openings of endometrium gland.
Figure 4
Figure 4
ETT cells arranged in the nest bulk, invading the muscle layer (arrows). Tissues were stained with HE. Image was taken at 200× magnification. ETT, epithelioid trophoblastic tumor.
Figure 5
Figure 5
ETT cells have neclei, clear cell boundaries, and transparent cytoplasm (arrows). Tissues were stained with HE. Image was taken at 200× magnification. ETT, epithelioid trophoblastic tumor.
Figure 6
Figure 6
Timeline of disease treatment process.
See this image and copyright information in PMC

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