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Review
. 1986 Jan;56(1):2-12.

Clinical and pharmacokinetic concerns of 24-hour dosing with theophylline

M Weinberger
  • PMID: 3511775
Review

Clinical and pharmacokinetic concerns of 24-hour dosing with theophylline

M Weinberger. Ann Allergy. 1986 Jan.

Abstract

Selection of the dosing interval for oral theophylline must consider the product's absorption rate, the patient's elimination rate, and the tolerated fluctuation in serum concentration. Attempts to produce formulations with ultra-slow absorption for "once daily" marketing have thus far resulted in incomplete and erratic absorption.

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