Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May;37(5):503-512.
doi: 10.1007/s10654-022-00843-y. Epub 2022 Feb 3.

Association of allergic diseases and epilepsy with risk of glioma, meningioma and acoustic neuroma: results from the INTERPHONE international case-control study

Brigitte Schlehofer  1 , Maria Blettner  2 , Monika Moissonnier  3 , Isabelle Deltour  3 , Graham G Giles  4   5   6 , Bruce Armstrong  7 , Jack Siemiatycki  8 , Marie-Elise Parent  9 , Daniel Krewski  10 , Christoffer Johansen  11 , Anssi Auvinen  12   13 , Anna Lahkola  13 , Martine Hours  14 , Gabriele Berg-Beckhoff  15 , Siegal Sadetzki  16   17   18 , Susanna Lagorio  19 , Toru Takebayashi  20 , Naohito Yamaguchi  21 , Alistair Woodward  22 , Angus Cook  23 , Tore Tynes  24 , Lars Klaboe  25 , Maria Feychting  26 , Richard Feltbower  27 , Anthony Swerdlow  28 , Minouk Schoemaker  28 , Elisabeth Cardis  29   30   31 , Joachim Schüz  32
Affiliations
Free article

Association of allergic diseases and epilepsy with risk of glioma, meningioma and acoustic neuroma: results from the INTERPHONE international case-control study

Brigitte Schlehofer et al. Eur J Epidemiol. 2022 May.
Free article

Abstract

We investigated the association of allergic diseases and epilepsy with risk of brain tumours, in Interphone, a 13-country case-control study. Data were obtained from 2693 glioma cases, 2396 meningioma cases, and 1102 acoustic neuroma cases and their 6321 controls. Conditional logistic regression models were used to estimate pooled odds ratios (ORs) and their respective 95% confidence intervals (CIs), adjusted for education and time at interview. Reduced ORs were observed for glioma in relation to physician-diagnosed asthma (OR = 0.73; CI 0.58-0.92), hay fever (OR 0.72; CI 0.61-0.86), and eczema (OR 0.78, CI 0.64-0.94), but not for meningioma or acoustic neuroma. Previous diagnosis of epilepsy was associated with an increased OR for glioma (2.94; CI 1.87-4.63) and for meningioma (2.12; CI 1.27-3.56), but not for acoustic neuroma. This large-scale case-control study adds to the growing evidence that people with allergies have a lower risk of developing glioma, but not meningioma or acoustic neuroma. It also supports clinical observations of epilepsy prior to the diagnosis of glioma and meningioma.

Keywords: Allergies; Brain tumours; Epilepsy; Multicenter case–control study.

PubMed Disclaimer

References

    1. Schlehofer B, Siegmund B, Linseisen J, et al. Primary brain tumours and specific serum immunoglobulin E: a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort. Allergy. 2011;66:1434–41. https://doi.org/10.1111/j.1398-9995.2011.02670.x . - DOI - PubMed
    1. Ostrom QT, Bauchet L, Davis FG, et al. The epidemiology of glioma in adults : a « state of the science » review. Neuro Oncol. 2014;16:896–913. https://doi.org/10.1093/neuonc/nou087 . - DOI - PubMed - PMC
    1. Turner MC, Krewski D, Armstrong BK, et al. Allergy and brain tumors in the INTERPHONE study: pooled results from Australia, Canada, France, Israel, and New Zealand. Cancer Causes Control. 2013;24:949–60. https://doi.org/10.1007/s10552-013-0171-7 . - DOI - PubMed
    1. Vecht CJ, Kerkhof M, Duran-Pena A. Seizure prognosis in brain tumors : new insights and evidence-based management. Oncologist. 2014;19:751–9. https://doi.org/10.1634/theoncologist.2014-0060 . - DOI - PubMed - PMC
    1. Prakash O, Lukiw WJ, Peruzzi F, et al. Gliomas and seizures. Med Hypotheses. 2012;79:622–6. - DOI

MeSH terms