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. 2022 Feb 4;101(5):e28519.
doi: 10.1097/MD.0000000000028519.

Choroidal vascularity index and thickness in sarcoidosis

Erhan Ugurlu  1 , Gokhan Pekel  2 , Selen Akbulut  2 , Nazli Cetin  1 , Sinan Durmus  1 , Goksel Altinisik  1
Affiliations

Choroidal vascularity index and thickness in sarcoidosis

Erhan Ugurlu et al. Medicine (Baltimore). .

Abstract

Sarcoidosis is a multisystem granulomatous disease which is observed worldwide. Sarcoidosis is one of the common causes of ocular inflammation. The choroidal vascularity index, defined as the ratio of the luminal area to the total choroidal area, is used as one of the biomarkers for assessing the choroid vascular state. We aimed to compare choroidal vascularity index and thickness measurements between sarcoidosis patients and healthy controls.Thirty-one patients with sarcoidosis and 31 age-gender matched healthy participants were recruited in this cross-sectional and comparative study. Choroidal vascularity index was defined as the ratio of luminal area to total choroidal area after binarization on optical coherence tomography images. Anterior segment examinations included central corneal thickness, corneal volume, anterior chamber depth, anterior chamber volume, and iridocorneal angle. Spectral-domain optical coherence tomography was used to measure peripapillary retinal nerve fiber layer thickness, choroidal thickness, and retinal vessel caliber.The mean choroidal vascularity index value was 61.6% in sarcoidosis patients and 62.4% in healthy controls (P = .69). The choroidal vascularity index and thickness were significantly correlated in both sarcoidosis (r = 0.41, P = .026) and control groups (r = 0.51, P = .006). Both the sarcoidosis and control groups had similar measured values for central corneal thickness, corneal volume, anterior chamber depth, anterior chamber volume, and iridocorneal angle (P > .05). Mean retinal nerve fiber layer, retinal arteriole and venule caliber, and choroidal thickness measurements did not differ significantly between the groups (P > .05).Sarcoidosis patients in quiescent period have similar choroidal vascularity index and thickness with healthy controls.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Binarization of an image of nasal peripapillary choroid is shown.
Figure 2
Figure 2
Retinal arteriolar (RAC) and venular caliber (RVC) measurement screen is shown (ITRA = infero-temporal retinal arteriole, ITRV = infero-temporal retinal venule, STRA = supero-temporal retinal arteriole, STRV = supero-temporal retinal venule).
Figure 3
Figure 3
Peripapillary choroidal thickness measurement screen is shown (white arrow heads show the border of the sclera and choroid).
See this image and copyright information in PMC

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