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Observational Study
. 2022 Feb 4;101(5):e28620.
doi: 10.1097/MD.0000000000028620.

Postoperative recurrence of gastric cancer depends on whether the chemotherapy cycle was more than 9 cycles: Based on a retrospective and observational study of follow-up within 3 years of 843 patients

Yifan Li  1 , Haoliang Zhao  2
Affiliations
Observational Study

Postoperative recurrence of gastric cancer depends on whether the chemotherapy cycle was more than 9 cycles: Based on a retrospective and observational study of follow-up within 3 years of 843 patients

Yifan Li et al. Medicine (Baltimore). .

Abstract

We retrospectively reviewed the medical records of patients with pathologically confirmed gastric cancer/adenocarcinoma who underwent curative surgical resection follow-up within 3 years at Shanxi cancer hospital between 2002 and 2020. The clinicopathologic parameters explored included gender, age at surgery, vascular invasion, neural invasion, Tumor infiltration depth (T stage), N stage, TNM stage, chemotherapy, Lauren classification, maximum diameter of tumor, type of gastrectomy, tumor location and survival data.With a median follow-up of 29 months (range 0-36 months), the ratio of patients with recurrence was 26.80% (n = 226) and the death rate of patients was 45.31% (n = 382) in this period. According to the results of univariate analysis, gender (P = .014), age at surgery (P = .010), vascular invasion (P = .000), neural invasion (P = .000), T stage (P = .000), N stage (P = .000), TNM stage (P = .000), chemotherapy cycle (P = .000), lauren classification (P = .000), maximum diameter of tumor (P = .000), type of gastrectomy (P = .000) were independent risk factors of recurrence of follow-up within 3 years. From the multivariate analysis by logistic regression showed that TNM Stage (P = .002), chemotherapy cycle (P = .000) were risk factors of recurrence of follow-up within 3 years. Univariate analysis of survival by Kaplan-Meier showed that gender (P = .038), vascular invasion (P = .000), neural invasion (P = .000), maximum diameter of tumor (P = .000), Lauren classification (P = .000), T stage (P = .000), N stage (P = .000), TNM Stage (P = .000) and type of gastrectomy (P = .000) were key factors linked to overall survival of follow-up within 3 years. The results of the multivariate analysis by Cox regression were clearly presented that T Stage (P = .000), TNM stage (P = .001), maximum diameter of tumor (P = .001) were key factors of overall survival of follow-up within 3 years.TNM Stage, chemotherapy cycle were closely related to recurrence and of follow-up within 3 years. More than 9 cycles of chemotherapy was able to reduce the probability of recurrence. T Stage, TNM stage, maximum diameter of tumor were independent factors associated with overall survival of gastric cancer of follow-up within 3 years. For maximum diameter of tumor, the probability of death of more than 6 cm was 1.317 times less than 6 cm within 3 years of follow-up.

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Conflict of interest statement

The authors have no funding and conflicts of interests to disclose.

Figures

Figure 1
Figure 1
OS curves for sex.
Figure 2
Figure 2
OS curves for vascular invasion.
Figure 3
Figure 3
OS curves for neural invasion.
Figure 4
Figure 4
OS curves for age.
Figure 5
Figure 5
OS curves for maximum diameter of tumor.
Figure 6
Figure 6
OS curves for chemotherapy cycle.
Figure 7
Figure 7
OS curves for Lauren classification.
Figure 8
Figure 8
OS curves for T stage.
Figure 9
Figure 9
OS curves for N stage.
Figure 10
Figure 10
OS curves for TNM.
Figure 11
Figure 11
OS curves for tumor location.
Figure 12
Figure 12
OS curves for type of gastrectomy Word count: 4310.
See this image and copyright information in PMC

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