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. 2022 Feb 4;101(5):e28703.
doi: 10.1097/MD.0000000000028703.

The rs1458038 variant near FGF5 is associated with poor response to calcium channel blockers among Filipinos

Felix Eduardo R Punzalan  1 , Eva Maria C Cutiongco-de la Paz  2   3 , Jose Jr B Nevado  2 , Jose Donato A Magno  1 , Deborah Ignacia D Ona  1 , Aimee Yvonne Criselle L Aman  2   3 , Marc Denver A Tiongson  1 , Elmer Jasper B Llanes  1 , Paul Ferdinand M Reganit  1 , Richard Henry P Tiongco 2nd  1 , Lourdes Ella G Santos  1 , Jaime Alfonso M Aherrera  1 , Lauro L Abrahan 4th  1 , Charlene F Agustin  1 , Adrian John P Bejarin  2   3 , Rody G Sy  1
Affiliations

The rs1458038 variant near FGF5 is associated with poor response to calcium channel blockers among Filipinos

Felix Eduardo R Punzalan et al. Medicine (Baltimore). .

Abstract

Genetic variation is known to affect response to calcium channel blockers (CCBs) among different populations. This study aimed to determine the genetic variations associated with poor response to this class of antihypertensive drugs among Filipinos.One hundred eighty one hypertensive participants on CCBs therapy were included in an unmatched case-control study. Genomic deoxyribonucleic acid were extracted and genotyped for selected genetic variants. Regression analysis was used to determine the association of genetic and clinical variables with poor response to medication.The variant rs1458038 near fibroblast growth factor 5 gene showed significant association with poor blood pressure-lowering response based on additive effect (CT genotype: adjusted OR 3.41, P = .001; TT genotype: adjusted OR 6.72, P < .001).These findings suggest that blood pressure response to calcium channels blockers among Filipinos with hypertension is associated with gene variant rs1458038 near fibroblast growth factor 5 gene. Further studies are recommended to validate such relationship of the variant to the CCB response.

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Conflict of interest statement

The authors have no conflicts of interests to disclose.

Figures

Figure 1
Figure 1
Overview of data processing and analysis. geno = genotypic missingness, HWE = Hardy-Weinberg equilibrium, MAF = minor allele frequency, mind = individual missingness, SNP = single nucleotide polymorphism.
See this image and copyright information in PMC

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