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Case Reports
. 2022 Sep 1;41(9):1174-1176.
doi: 10.1097/ICO.0000000000002981. Epub 2022 Feb 4.

Corneal Endothelial Dysfunction as a Manifestation of Digoxin Toxicity

Angi Lizbeth Mendoza-Moreira  1 , Sara Rodrigo-Rey, María Belén Figuerola-García, Ángela González-Alonso, María Teresa Marcos-Parra, Juan J Pérez-Santonja
Affiliations
Case Reports

Corneal Endothelial Dysfunction as a Manifestation of Digoxin Toxicity

Angi Lizbeth Mendoza-Moreira et al. Cornea. .

Abstract

Purpose: The purpose of this study was to report a case of corneal endothelial dysfunction and subsequent corneal edema in a patient with digoxin toxicity.

Method: This was a case report.

Results: A 77-year-old woman diagnosed with open-angle glaucoma and treated with a topical prostaglandin analog for 5 years developed blurred vision and photopsia in both eyes. Systemic medications included digoxin, furosemide, apixaban, amlodipine, enalapril, and simvastatin. Ocular examination revealed folds in Descemet membrane and corneal stromal edema in both eyes, with normal fundoscopy. Ancillary tests revealed elevated serum digoxin levels. No intervention other than discontinuation of digoxin was initiated. The corneal edema improved after that and resolved in the next 2 weeks.

Conclusions: We encountered 1 case of corneal edema secondary to corneal endothelial dysfunction in a patient with digoxin toxicity. Special care should be taken to elicit a complete history because ocular signs can be manifestations of systemic alterations with vital importance for patients.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

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