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Comment
. 2022 Feb 14;40(2):122-124.
doi: 10.1016/j.ccell.2022.01.005. Epub 2022 Feb 3.

Inflammatory fibroblasts make rectal cancer resistant to radiation therapy

Rana Mhaidly  1 , Fatima Mechta-Grigoriou  2
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Free article
Comment

Inflammatory fibroblasts make rectal cancer resistant to radiation therapy

Rana Mhaidly et al. Cancer Cell. .
Free article

Abstract

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Still, the molecular mechanisms that drive CRC therapy resistance are incompletely understood. In this issue of Cancer Cell, Nicolas et al. combine several approaches to unravel a critical role for inflammatory cancer-associated fibroblasts (iCAFs) and interleukin 1α (IL1α) signaling in radiotherapy resistance.

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Conflict of interest statement

Declaration of interests F.M-G. received research support from Innate-Pharma, Roche and Bristol-Myers-Squibb (BMS). R.M. declares no potential conflict of interest.

Comment on

  • Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer.
    Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR. Nicolas AM, et al. Cancer Cell. 2022 Feb 14;40(2):168-184.e13. doi: 10.1016/j.ccell.2022.01.004. Epub 2022 Feb 3. Cancer Cell. 2022. PMID: 35120600

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