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. 2022 Feb 14;40(2):109-113.
doi: 10.1016/j.ccell.2022.01.012. Epub 2022 Feb 3.

New genomic technologies for multi-cancer early detection: Rethinking the scope of cancer screening

Allan Hackshaw  1 , Christina A Clarke  2 , Anne-Renee Hartman  2
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Free article

New genomic technologies for multi-cancer early detection: Rethinking the scope of cancer screening

Allan Hackshaw et al. Cancer Cell. .
Free article

Abstract

Cancers other than breast, colorectal, cervical, and lung do not have guideline-recommended screening. New multi-cancer early detection (MCED) tests-using a single blood sample-have been developed based on circulating cell-free DNA (cfDNA) or other analytes. In this commentary, we review the current evidence on these tests, provide several major considerations for new MCED tests, and outline how their evaluation will need to differ from that established for traditional single-cancer screening tests.

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Conflict of interest statement

Declaration of interests C.A.C. is an employee of GRAIL, LLC, and holds stock in the company. A.-R.H. is a former employee of GRAIL and holds stock in the company and is currently employed by Adela, Inc. A.H. is an investigator for an academic study (SUMMIT) sponsored by University College London that is funded by GRAIL, has received one honorarium for an advisory board meeting for GRAIL, received a consulting fee from Evidera Inc. (for a GRAIL-initiated project), and has previously owned shares in Illumina, Inc. He did not receive any compensation for his work on this manuscript. A.H. is supported by a Cancer Research UK grant to University College London (C444/A15953).

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