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Comment
. 2022 Feb 3;29(2):177-179.
doi: 10.1016/j.stem.2022.01.009.

A microbiome-macrophage-iron axis guides stressed hematopoietic stem cell fate

Francisco Caiado  1 , Markus G Manz  2
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A microbiome-macrophage-iron axis guides stressed hematopoietic stem cell fate

Francisco Caiado et al. Cell Stem Cell. .
Free article

Abstract

The mammalian microbiota is a recently recognized regulator of hematopoiesis. In this issue of Cell Stem Cell, Zhang et al. (2022) show in mice that microbiota-derived butyrate enhances bone marrow macrophage erythrophagocytosis-dependent iron availability, which supports stress-induced hematopoietic stem cell differentiation and blood regeneration.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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