Cut out that YAPping: Mechanisms to reduce scar formation
- PMID: 35120615
- DOI: 10.1016/j.stem.2022.01.005
Cut out that YAPping: Mechanisms to reduce scar formation
Abstract
Tissue repair in adult mammals lacks the regenerative ability of many tissues in other adult organisms like axolotl and newts. In this issue of Cell Stem Cell, Mascharak et al. use multi-omics approaches to identify an essential role for the transcription factor Trps1 in Yap-inhibited fibroblasts' tissue regenerative responses in murine skin.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing.Cell Stem Cell. 2022 Feb 3;29(2):315-327.e6. doi: 10.1016/j.stem.2021.12.011. Epub 2022 Jan 24. Cell Stem Cell. 2022. PMID: 35077667 Free PMC article.
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