Quickly moving too slowly: Interneuron migration in Timothy Syndrome

Michael B Fernando¹, Kristen J Brennand²

Affiliations

¹ Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Nash Family Department of Neuroscience, Friedman Brain Institute, Pamela Sklar Division of Psychiatric Genomics, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
² Nash Family Department of Neuroscience, Friedman Brain Institute, Pamela Sklar Division of Psychiatric Genomics, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: kristen.brennand@yale.edu.

PMID: 35120616
DOI: 10.1016/j.stem.2022.01.004

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Quickly moving too slowly: Interneuron migration in Timothy Syndrome

Michael B Fernando et al. Cell Stem Cell. 2022.

Free article

. 2022 Feb 3;29(2):181-183.

doi: 10.1016/j.stem.2022.01.004.

Authors

Michael B Fernando¹, Kristen J Brennand²

Affiliations

¹ Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Nash Family Department of Neuroscience, Friedman Brain Institute, Pamela Sklar Division of Psychiatric Genomics, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
² Nash Family Department of Neuroscience, Friedman Brain Institute, Pamela Sklar Division of Psychiatric Genomics, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: kristen.brennand@yale.edu.

PMID: 35120616
DOI: 10.1016/j.stem.2022.01.004

Abstract

Aberrant migration of GABAergic interneurons during cortical neurodevelopment is implicated in Timothy Syndrome, yet the underlying mechanisms remain elusive. In this issue of Cell Stem Cell, Birey et al. model developing brain circuitry using "assembloids" from patients, characterizing a bimodal mechanism of mechano-chemically driven interneuron migration inefficiencies.

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Conflict of interest statement

Declarations of interest The authors declare no competing interests.

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Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome.
Birey F, Li MY, Gordon A, Thete MV, Valencia AM, Revah O, Paşca AM, Geschwind DH, Paşca SP. Birey F, et al. Cell Stem Cell. 2022 Feb 3;29(2):248-264.e7. doi: 10.1016/j.stem.2021.11.011. Epub 2022 Jan 5. Cell Stem Cell. 2022. PMID: 34990580

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Quickly moving too slowly: Interneuron migration in Timothy Syndrome

Affiliations

Quickly moving too slowly: Interneuron migration in Timothy Syndrome

Authors

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Abstract

Conflict of interest statement

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Supplementary concepts

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