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Comment
. 2022 Feb 3;82(3):500-502.
doi: 10.1016/j.molcel.2022.01.003.

ecDNAs personify cancer gangsters

Tina Keshavarzian  1 , Mathieu Lupien  2
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ecDNAs personify cancer gangsters

Tina Keshavarzian et al. Mol Cell. .
Free article

Abstract

Alterations to gene regulatory plexuses typify oncogenesis, and two recent studies from Hung, Yost, Xie et al. (Hung et al., 2021) and Yi et al. (2021) collectively reveal the competitive advantage of extrachromosomal DNAs (ecDNAs) to set their own rules to control transcription by clustering into ecDNA hubs through intermolecular interactions that forge hub-specific regulatory plexuses driving high-oncogene expression.

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Declaration of interests The authors declare no competing interests.

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