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Review
. 2022 Apr:58:101450.
doi: 10.1016/j.molmet.2022.101450. Epub 2022 Feb 2.

Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation

Kaiting Ning  1 , Shiqiang Liu  1 , Baoqiang Yang  1 , Rui Wang  1 , Guigui Man  1 , Dong-En Wang  1 , Huiyun Xu  2
Affiliations
Review

Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation

Kaiting Ning et al. Mol Metab. 2022 Apr.

Abstract

Background: As common progenitor cells of osteoblasts and adipocytes, bone marrow mesenchymal (stromal) stem cells (BMSCs) play key roles in bone homeostasis, tissue regeneration, and global energy homeostasis; however, the intrinsic mechanism of BMSC differentiation is not well understood. Plasticity in energy metabolism allows BMSCs to match the divergent demands of osteo-adipogenic differentiation. Targeting BMSC metabolic pathways may provide a novel therapeutic perspective for BMSC differentiation unbalance related diseases.

Scope of review: This review covers the recent studies of glucose, fatty acids, and amino acids metabolism fuel the BMSC differentiation. We also discuss recent findings about energy metabolism in BMSC differentiation.

Major conclusions: Glucose, fatty acids, and amino acids metabolism provide energy to fuel BMSC differentiation. Moreover, some well-known regulators including environmental stress, hormone drugs, and biological and pathological factors may also influence BMSC differentiation by altering metabolism. This offers insight to the significance of metabolism on BMSC fate determination and provides the possibility of treating diseases related to BMSC differentiation, such as obesity and osteoporosis, from a metabolic perspective.

Keywords: Biological factors; Bone marrow mesenchymal (stromal) stem cells differentiation; Energy metabolism; Environmental factors; Hormone drugs; Pathological factors.

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Figures

Figure 1
Figure 1
The role of energy metabolism during BMSC differentiation. Glucose, fatty acids, and amino acid participate in BMSC differentiation. Moreover, environmental stress, hormone drugs, biological factors, and pathological factors influence differentiation by altering metabolism.
See this image and copyright information in PMC

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