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Review
. 2020 Oct;1(10):946-964.
doi: 10.1038/s43018-020-00122-3. Epub 2020 Oct 2.

The immuno-oncological challenge of COVID-19

Lisa Derosa  1   2   3 , Cléa Melenotte  1   2   4   5 , Franck Griscelli  1   6 , Bertrand Gachot  1   7 , Aurélien Marabelle  1   2   3 , Guido Kroemer  8   9   10   11   12 , Laurence Zitvogel  13   14   15   16   17
Affiliations
Review

The immuno-oncological challenge of COVID-19

Lisa Derosa et al. Nat Cancer. 2020 Oct.

Erratum in

Abstract

Coronavirus disease 2019 (COVID-19) and its causative virus, SARS-CoV-2, pose considerable challenges for the management of oncology patients. COVID-19 presents as a particularly severe respiratory and systemic infection in aging and immunosuppressed individuals, including patients with cancer. Moreover, severe COVID-19 is linked to an inflammatory burst and lymphopenia, which may aggravate cancer prognosis. Here we discuss why those with cancer are at higher risk of severe COVID-19, describe immune responses that confer protective or adverse reactions to this disease and indicate which antineoplastic therapies may either increase COVID-19 vulnerability or have a dual therapeutic effect on cancer and COVID-19.

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