Carpet-bombing tumors with IFN-γ

Affiliations

¹ Department of Pathology and ImmunoX, University of California, San Francisco, San Francisco, CA, USA.
² Department of Pathology and ImmunoX, University of California, San Francisco, San Francisco, CA, USA. matthew.krummel@ucsf.edu.

Comment

Kenneth H Hu et al. Nat Cancer. 2020 Mar.

. 2020 Mar;1(3):270-272.

doi: 10.1038/s43018-020-0042-6.

¹ Department of Pathology and ImmunoX, University of California, San Francisco, San Francisco, CA, USA.
² Department of Pathology and ImmunoX, University of California, San Francisco, San Francisco, CA, USA. matthew.krummel@ucsf.edu.

No abstract available

Comment on

Long-distance modulation of bystander tumor cells by CD8⁺ T cell-secreted IFNγ.
Hoekstra ME, Bornes L, Dijkgraaf FE, Philips D, Pardieck IN, Toebes M, Thommen DS, van Rheenen J, Schumacher TNM. Hoekstra ME, et al. Nat Cancer. 2020 Mar;1(3):291-301. doi: 10.1038/s43018-020-0036-4. Epub 2020 Mar 9. Nat Cancer. 2020. PMID: 32566933 Free PMC article.
Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.
Thibaut R, Bost P, Milo I, Cazaux M, Lemaître F, Garcia Z, Amit I, Breart B, Cornuot C, Schwikowski B, Bousso P. Thibaut R, et al. Nat Cancer. 2020 Mar;1(3):302-314. doi: 10.1038/s43018-020-0038-2. Epub 2020 Mar 9. Nat Cancer. 2020. PMID: 32803171 Free PMC article.

1. Alspach, E., Lussier, D. M. & Schreiber, R. D. Cold Spring Harb. Perspect. Biol. https://doi.org/10.1101/cshperspect.a028480 (2019). - DOI - PubMed
1. Hoekstra, M. E., Bornes, L., Dijkgraaf, F. E., Philips, D. & Pardieck, I. N. Nat. Cancer https://doi.org/10.1038/s43018-020-0036-4 (2020).
1. Thibaut, R. et al. Nat. Cancer https://doi.org/10.1038/s43018-020-0038-2 (2020).
1. Huse, M., Lillemeier, B. F., Kuhns, M. S., Chen, D. S. & Davis, M. M. Nat. Immunol. 7, 247–255 (2006). - DOI
1. Sanderson, N. S. R. et al. Proc. Natl Acad. Sci. USA 109, 7835–7840 (2012). - DOI