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. 2022 Jun;129(5-6):575-580.
doi: 10.1007/s00702-021-02451-8. Epub 2022 Feb 5.

The reduction of hippocampal volume in Parkinson's disease

Pavel Říha  1   2 , Luboš Brabenec  2 , Radek Mareček  2 , Ivan Rektor  3   4 , Irena Rektorová  5   2
Affiliations

The reduction of hippocampal volume in Parkinson's disease

Pavel Říha et al. J Neural Transm (Vienna). 2022 Jun.

Abstract

The volume of the hippocampus decreases more slowly than the volume of the cortex during normal aging. We explored changes in the hippocampus-to-cortex volume (HV:CTV) ratio with increasing age in non-demented Parkinson's disease (PD) patients as compared to healthy controls (HC). We also evaluated the association between the HV:CTV ratio and cognitive outcomes. Altogether 130 participants without dementia aged 51-88 years were consecutively enrolled, including 54 PD patients (mean age 67, standard deviation (SD) 8 years) and 76 HC (mean age 69, SD 7 years). All participants underwent structural magnetic resonance examination and psychological evaluation. Hippocampal and cortex volumes were determined from T1 and FLAIR scans using FreeSurfer software, and the HV:CTV ratio was calculated. Regression lines for age-dependence of the HV:CTV ratio for PD and HC groups were calculated. We further assessed the association between the HV:CTV ratio and cognitive tests examining hippocampus-related cognitive functions. PD patients and age-matched HC showed a significant difference in age-dependence of HV:CTV ratio (p value = 0.012), with a decreasing slope in PD and increasing slope in HC. In the PD group, a significant correlation (R = 0.561, p = 0.024) was observed between the HV:CTV ratio and the Digit Symbol-Coding test. The reduction of HV:CTV ratio is accelerated in pathological aging due to PD pathology. The HV:CTV ratio was associated with impaired processing speed, i.e., the cognitive function that is linked to subcortical alterations of both associated basal ganglia circuitry and the hippocampus.

Keywords: Aging; Hippocampus-to-cortex volume ratio; Parkinson’s disease; Processing speed.

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