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. 2022 May;108(5):437-445.
doi: 10.1111/ejh.13752. Epub 2022 Feb 14.

Incidence and socioeconomic factors in older adults with acute myeloid leukaemia: Real-world outcomes from a population-based cohort

Ryan J Stubbins  1   2   3 , Maria Stamenkovic  2 , Claudie Roy  1   2 , Judith Rodrigo  1   2 , Shanee Chung  1   2 , Florian C Kuchenbauer  1   2   4 , Kevin A Hay  1   2   4 , Jennifer White  1   2 , Yasser Abou Mourad  1   2 , Maryse M Power  1   2 , Sujaatha Narayanan  1   2 , Donna L Forrest  1   2 , Cynthia L Toze  1   2 , Heather J Sutherland  1   2 , Stephen H Nantel  1   2 , Thomas J Nevill  1   2 , Aly Karsan  1   2   3 , Kevin W Song  1   2 , David S Sanford  1   2
Affiliations

Incidence and socioeconomic factors in older adults with acute myeloid leukaemia: Real-world outcomes from a population-based cohort

Ryan J Stubbins et al. Eur J Haematol. 2022 May.

Abstract

Objectives: Acute myeloid leukaemia (AML) is a disease of older adults, who are vulnerable to socio-economic factors. We determined AML incidence in older adults and the impact of socio-economic factors on outcomes.

Methods: We included 3024 AML patients (1996-2016) identified from a population-based registry.

Results: AML incidence in patients ≥60 years increased from 11.01 (2001-2005) to 12.76 (2011-2016) per 100 000 population. Among 879 patients ≥60 years in recent eras (2010-2016), rural residents (<100 000 population) were less likely to be assessed by a leukaemia specialist (39% rural, 47% urban, p = .032); no difference was seen for lower (43%, quintile 1-3) vs. higher (47%, quintile 4-5) incomes (p = .235). Similar numbers received induction chemotherapy between residence (16% rural, 18% urban, p = .578) and incomes (17% lower, 17% high, p = 1.0). Differences between incomes were seen for hypomethylating agent treatment (14% low, 20% high, p = .041); this was not seen for residence (13% rural, 18% urban, p = .092). Among non-adverse karyotype patients ≥70 years, 2-year overall survival was worse for rural (5% rural, 12% urban, p = .006) and lower income (6% low, 15% high, p = .017) patients.

Conclusions: AML incidence in older adults is increasing, and outcomes are worse for older rural and low-income residents; these patients face treatment barriers.

Keywords: acute myeloid leukaemia; epidemiology; incidence; older adults; social disparity.

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References

REFERENCES

    1. National Cancer Institute Surveillance E, and End Results Program. 2019 Cancer Stat Facts: Leukemia-Acute Myeloid Leukemia. https://seer.cancer.gov/statfacts/html/amyl.html
    1. Sekeres MA, Guyatt G, Abel G, et al. American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults. Blood Adv. 2020;4:3528-3549.
    1. Bureau USC. Projected Age Groups and Sex Composition of the Population: Main Projections Series for the United States, 2017-2060. Census Bureau; 2018.
    1. Juliusson G, Antunovic P, Derolf A, et al. Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry. Blood. 2009;113:4179-4187.
    1. Chen Y, Yang T, Zheng X, et al. The outcome and prognostic factors of 248 elderly patients with acute myeloid leukemia treated with standard-dose or low-intensity induction therapy. Medicine (Baltimore). 2016;95:e4182.

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